Doxorubicin: the good, the bad and the ugly effect
The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers. …
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers. …
Doxorubicin‐induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy
Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been …
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been …
Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species
…, S Amaral, PJ Oliveira - Current diabetes …, 2008 - ingentaconnect.com
Diabetes Mellitus (DM), a state of chronic hyperglycemia, is a major cause of serious micro
and macrovascular diseases, affecting, therefore, nearly every system in the body. Growing …
and macrovascular diseases, affecting, therefore, nearly every system in the body. Growing …
Mitochondrial determinants of doxorubicin-induced cardiomyopathy
KB Wallace, VA Sardão, PJ Oliveira - Circulation research, 2020 - Am Heart Assoc
Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity
PJ Oliveira, JA Bjork, MS Santos, RL Leino… - Toxicology and applied …, 2004 - Elsevier
The cardiotoxicity associated with doxorubicin (DOX) therapy limits the total cumulative
dose and therapeutic success of active anticancer chemotherapy. Cardiac mitochondria are …
dose and therapeutic success of active anticancer chemotherapy. Cardiac mitochondria are …
Benchmark solutions for the flow of Oldroyd-B and PTT fluids in planar contractions
The paper presents very accurate numerical results for the vortex size, the vortex intensity
and the Couette correction, in planar contraction flows of Oldroyd-B and PTT fluids (ε=0.25) …
and the Couette correction, in planar contraction flows of Oldroyd-B and PTT fluids (ε=0.25) …
Numerical simulation of non-linear elastic flows with a general collocated finite-volume method
PJ Oliveira, FT Pinho, GA Pinto - Journal of Non-Newtonian Fluid …, 1998 - Elsevier
This paper reports the development and application of a finite-volume based methodology for
the calculation of the flow of fluids which follow differential viscoelastic constitutive models. …
the calculation of the flow of fluids which follow differential viscoelastic constitutive models. …
Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells
10.7554/eLife.22187.001 Recently, we showed that generation of tumours in syngeneic mice
by cells devoid of mitochondrial (mt) DNA (ρ 0 cells) is linked to the acquisition of the host …
by cells devoid of mitochondrial (mt) DNA (ρ 0 cells) is linked to the acquisition of the host …
Parabens in male infertility—Is there a mitochondrial connection?
…, FC Martins, PJ Oliveira, J Ramalho-Santos… - Reproductive …, 2009 - Elsevier
Parabens are widely used as preservatives in many foods, cosmetics, toiletries, and
pharmaceuticals due to their relatively low toxicity profile and to a long history of safe use. Parabens …
pharmaceuticals due to their relatively low toxicity profile and to a long history of safe use. Parabens …
Purely elastic flow asymmetries
Using a numerical technique we demonstrate that the flow of the simplest differential
viscoelastic fluid model (ie, the upper-convected Maxwell model) goes through a bifurcation to a …
viscoelastic fluid model (ie, the upper-convected Maxwell model) goes through a bifurcation to a …