In the fission yeast S. pombe the c&25+ gene function is required to initiate mitosis. We have
cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis …

Fission yeast w-eel-mutants initiate mitosis at half the cell size of wild type. The weeI+ activity
is required to prevent lethal premature mitosis in cells that overproduce the mitotic inducer …

Mouse hearts were transplanted heterotopically as primarily vascularized grafts. Donors and
recipients were selected to provide combinations in which there was histoincompatibility …

Mus81, a fission yeast protein related to the XPF subunit of ERCC1-XPF nucleotide excision
repair endonuclease, is essential for meiosis and important for coping with stalled …

DNA damage activates a cell-cycle checkpoint that prevents mitosis while DNA repair is under
way 1 . The protein Chk1 enforces this checkpoint by phosphorylating the mitotic inducer …

The EP300 protein is a histone acetyltransferase 1, 2 that regulates transcription via chromatin
remodelling 3 and is important in the processes of cell proliferation 4 and differentiation 5. …

Arrest of the cell cycle at the G 2 checkpoint, induced by DNA damage, requires inhibitory
phosphorylation of the kinase Cdc2 in both fission yeast and human cells. The kinase Wee1 …

In this review, we compare the reported values of Young's modulus (YM) obtained from
indentation and tensile deformations of soft biological tissues. When the method of deformation is …

In fission yeast, the M‐phase inducing kinase, a complex of p34cdc2 and cyclin B, is maintained
in an inhibited state during interphase due to the phosphorylation of Cdc2 at Tyr15. This …

Mutations in the BRCA1 gene, discovered in 1994, are associated with an 80–90% lifetime
risk of breast cancer. We have analysed 60 families with a history of breast and/or ovarian …