It is evident that in the last decade or so, a vast amount of new information has become
available concerning the various 5-HT receptor types and their characteristics. This derives from …

Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant
until it was reported to be associated with valvular heart disease. The valvular changes …

A complementary DNA clone encoding a transporter for glycine has been isolated from rat
brain, and its functional properties have been examined in mammalian cells. The transporter …

Presenilins are integral membrane protein involved in the production of amyloid β-protein.
Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease …

An intronless gene encoding an additional human serotonin (5-HT) 5-HT1-like receptor subtype
was isolated from a human genomic library with probes obtained from degenerate PCR …

Molecular cloning studies have revealed the existence of three subtypes of alpha 1-adrenergic
receptors. However, the link between any individual subtype and its functional role in the …

cDNA clones encoding two novel gamma-aminobutyric acid (GABA) transporters (designated
GAT-2 and GAT-3) have been isolated from rat brain, and their functional properties have …

A cDNA clone (designated rB16a) encoding a taurine transporter has been isolated from rat
brain, and its functional properties have been examined in mammalian cells. The nucleotide …

The serotonin 1D (5-HT1D) receptor is a pharmacologically defined binding site and
functional receptor site. Observed variations in the properties of 5-HT1D receptors in different …

RNA encoding the rat serotonin 5-HT 2C receptor undergoes editing whereby one to four
adenosines are converted to inosines. This conversion can change up to three codons out of a …