Preeclampsia complicates 5–8% of all pregnancies worldwide, and although its pathophysiology
remains obscure, placental oxidative stress and mitochondrial abnormalities are …

Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10
cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves …

Introduction Impaired utero-placental perfusion is a well-known feature of early preeclampsia
and is associated with placental hypoxia and oxidative stress. Although aberrations at the …

We evaluated the relationship between the presence of adrenergic nerves and the presence
of alpha-1 adrenoceptors (alpha-1 AR) in the arterial tree of the rat. The thoracic aorta and …

Preeclampsia (PE) is a pregnancy-related disorder characterized by hypertension and
proteinuria that affects 3–10% of all pregnancies. Although its pathophysiology remains obscure, …

OBJECTIVE: The objective was to test the hypothesis that women with a recent history of
preeclampsia have abnormalities in renal hemodynamics and volume status. STUDY DESIGN: …

Objective— Tissue kallikrein (TK) participates in acute flow-induced dilatation (FID) of large
arteries. We investigated whether TK deficiency blunts FID and alters chronic flow-related …

It is poorly understood how mechanical stimuli influence in vivo myocardial remodeling
during chronic hemodynamic overload. Combined quantitation of ventricular mechanics and …

Introduction Preeclampsia is a major health problem in human pregnancy, severely complicating
5–8% of all pregnancies. The emerging molecular mechanism is that conditions like …

We evaluated whether chronic $$,-adrenergic stimulation, angiotensin II (All), or increased
blood pressure (BP) alters resistance arterial structure and function. Structural parameters …