Lactic acid inhibits lipopolysaccharide-induced mast cell function by limiting glycolysis and ATP availability

…, TT Haque, MT Taruselli, PA Paez… - The Journal of …, 2019 - journals.aai.org
Sepsis has a well-studied inflammatory phase, with a less-understood secondary
immunosuppressive phase. Elevated blood lactate and slow lactate clearance are associated with …

Improving Cell and Gene Therapy Safety and Performance using Next-Generation NanoplasmidTM Vectors

JA Williams, PA Paez - Molecular Therapy-Nucleic Acids, 2023 - cell.com
The cell and gene therapy industry has employed the same plasmid technology for decades
in vaccination, cell and gene therapy, and as a raw material in viral vector and RNA …

TGF-β1 suppresses IL-33–induced mast cell function

…, D Abebayehu, AJ Spence, PA Paez… - The Journal of …, 2017 - journals.aai.org
TGF-β1 is involved in many pathological conditions, including autoimmune disorders,
cancer, and cardiovascular and allergic diseases. We have previously found that TGF-β1 can …

[HTML][HTML] Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity

X Yu, W Liu, S Chen, X Cheng, PA Paez… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background The efficacy of cancer immunotherapy can be limited by the poor immunogenicity
of cancer and the immunosuppressive tumor microenvironment (TME). Immunologically …

Fluvastatin induces apoptosis in primary and transformed mast cells

PA Paez, M Kolawole, MT Taruselli, S Ajith… - … of Pharmacology and …, 2020 - ASPET
Statin drugs are widely employed in the clinic to reduce serum cholesterol. Because of their
hydroxymethylglutaryl coenzyme A reductase antagonism, statins also reduce isoprenyl …

Stat5B is required for IgE-mediated mast cell function in vitro and in vivo

…, EM Kolawole, JJA Mcleod, B Baker, PA Paez… - Cellular …, 2021 - Elsevier
Mast cells are found primarily at interfaces with the external environment, where they provide
protection from pathogens but also elicit allergic inflammation. Mast cell activation by …

A Novel Immunostimulatory Platform for Amplifying the Abscopal Response Rates of Radiation Therapy

PA Paez - 2021 - scholarscompass.vcu.edu
Radiation therapy (RT) is one of the primary treatment modalities for head and neck squamous
cell carcinoma (HNSCC). At the time of diagnosis two-thirds of HNSCC patients have …

The HMGCR inhibitor Fluvastatin induces apoptosis and autophagy in primary and neoplastic mast cells

BO Barnstein, PA Paez, EM Kolawole… - The Journal of …, 2017 - journals.aai.org
Mast cells are best known for their role in inflammatory and allergic disease. Mast cell leukemia
is a rare subtype of acute myelogenous leukemia, typically expressing the c-Kit mutation, …

Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells

PA Paez - 2016 - scholarscompass.vcu.edu
Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs)
in patients with hypocholesteremia. In addition to their cholesterol-lowering effects …

Amplifying an abscopal effect of radiation therapy with a novel immunotherapeutic agent

PA Paez, W Liu, C Guo, R Mikkelsen… - The Journal of …, 2020 - journals.aai.org
Radiation therapy (RT) is one of the primary treatment modalities for head and neck squamous
cell carcinoma (HNSCC). At the time of diagnosis two-thirds of HNSCC patients have …