Raloxifene, [2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
hydrochloride (2), is representative of a class of compounds known as …

The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM)
which is currently under clinical evaluation for the prevention and treatment of …

Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein
that antagonizes many members of the family, including activin A, growth differentiation …

We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious
progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. …

The high regenerative capacity of adult skeletal muscle relies on a self-renewing depot of
adult stem cells, termed muscle satellite cells (MSCs). Androgens, known mediators of overall …

Activin A, a member of the transforming growth factor-β superfamily, provides pleiotropic
regulation of fibrosis and inflammation. We aimed at determining whether selective inhibition of …

Introduction: There is evidence that supports a role for Vitamin D (Vit. D) in muscle. The
exact mechanism by which Vit. D deficiency impairs muscle strength and function is not clear. …

A selective estrogen receptor modulator (SERM) for the potential treatment of hot flushes is
described. (R)-(+)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5H-6-oxachrysen-2-ol, …

Selective estrogen receptor modulators are an emerging class of pharmaceutically important
molecules. Many compounds in this class contain an aminoethoxyaryl moiety attached to a …

The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related
orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the …