Structure-activity relation studies have established that the alkyl side chain in tetrahydrocannabinol
(THC) plays a crucial role in the activation of the cannabinoid receptor. Unfortunately, …

We report a series of 28 pediatric carbon monoxide exposures. Sixteen patients (57%) were
judged to have potentially toxic carboxyhemeglobin (COHb) levels (greater than 15%). In …

The role of the oxygen of the benzopyran substituent of Δ 9 -tetrahydrocannabinol in defining
affinity for brain cannabinoid (CB 1 ) receptors is not well understood; however, it is known …

The photolysis of 3-(4-tolyl)-3-(trifluoromethyl) diazirine in the presence of benzene, methanol,
carbon tetrachloride, cyclohexane, triethylsilane, or diethylamine led to photoproducts …

3-p-Tolyl-3-trifluoromethyldiazirine was studied by laser flash photolysis (LFP) to obtain the
absolute kinetics of p-tolyl(trifluoromethyl)carbene 1. The absolute rate constants for the …

BACKGROUND: Historically, pain has been poorly managed in the pediatric emergency
department (ED) (PED), resulting in measurable psychosocial issues both acute and delayed. …

Structure-function analysis with a series of N-sulfonyloxy β-lactam molecules as inhibitors of
β-lactamases is reported. The best of these compounds acylate the active site of the class A …

Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine
transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro …

A novel quantitative structure−activity relationship (QSAR) for the side-chain region of Δ 8 -tetrahydrocannabinol
(Δ 8 -THC) analogues is reported. A series of 36 side-chain-substituted …

New heterobifunctional cross-linking reagents were developed that possess a photoactive
tetrafluori-nated phenyl azide as the photoactive terminus and a chemically reactive …