The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non-…

The ability of synapses to modify their synaptic strength in response to activity is a fundamental
property of the nervous system and may be an essential component of learning and …

The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate,
acts on three classes of ionotripic glutamate receptors, named after the agonists AMPA (α-…

The mechanisms involved in mossy fiber LTP in the hippocampus are not well established.
In the present study, we show that the kainate receptor antagonist LY382884 (10 μM) is …

Compared with NMDA receptor-dependent LTP, much less is known about the mechanism
of induction of NMDA receptor-independent LTP; the most extensively studied form of which …

Glutamatergic hyperactivity is implicated migraine pathogenesis. Also, LY293558, an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA)/kainate (KA) receptor antagonist, …

… To identify the best place on the aromatic ring to incorporate this group, we prepared BIs
with a methyl group at each of the four substitutable positions on the aromatic ring. To this end, …

Developments in the molecular biology and pharmacology of GLU K5 , a subtype of the
kainate class of ionotropic glutamate receptors, have enabled insights into the roles of this …

Activation of kainate receptors depresses excitatory synaptic transmission in the
hippocampus. In the present study, we have utilised a GluR5 selective agonist, ATPA [(RS)-2-amino-3-(3…

In order to study the roles of the AMPA and kainate subtypes of non-NMDA glutamate receptors
in the processing of persistent nociceptive information, compounds with varying activities …