We evaluated the safety, pharmacokinetic profile, pharmacodynamic effects, and antitumor
activity of abemaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDK) 4 …

Protein kinase C (PKC), a family of serine/threonine-specific kinases, plays a key role in cell
growth, metabolism, and differentiation. 1 Because the activated enzyme has been impli-…

The human inflammatory response can result in the alteration of drug clearance through
effects on metabolizing enzymes or transporters. In this article we briefly review the theory of …

… Both inhibitors were substrates for xenobiotic efflux transporters P-glycoprotein and breast
cancer resistant protein expressed at the blood–brain barrier. Brain K p,uu values were less …

… Statistical significance (p < 0.05) was determined using Student's t test or one-way analysis
… Barbuch, and P. Kulanthaivel, manuscript in preparation). The unusually large diamagnetic …

Herein we demonstrate that a small panel of variants of cytochrome P450 BM3 from Bacillus
megaterium covers the breadth of reactivity of human P450s by producing 12 of 13 …

Purpose: p38 MAPK regulates the production of cytokines in the tumor microenvironment
and enables cancer cells to survive despite oncogenic stress, radiotherapy, chemotherapy, …

… and/or repeated exposure to capsaicin has also been shown to cause a Ca 2+ -dependent
desensitization in peripheral sensory neurons due, in part, to depletion of substance P from …

… Streptavidin-coated PVT SPA beads and [ 33 P]ATP are the two most expensive components
of the SPA-based HTS and, furthermore, a large amount of 33 P radioactive waste is also a …

… ) relationship for p-Rb inhibition, the popPK model developed in this work was combined
with the previously developed pre-clinical semi-mechanistic PK/PD model [9] to simulate the p-…