Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1, 2-dichlorovinyl)-L-cysteine and S-(1, 2-dichlorovinyl)-L-cysteine sulfoxide.
LH Lash, PJ Sausen, RJ Duescher, AJ Cooley… - … of Pharmacology and …, 1994 - ASPET
Effects of S-(1,2-dichlorovinyl)-L-cysteine (DCVC) and its putative metabolite DCVC sulfoxide
(DCVCO) on renal function in vivo and in vitro were investigated to assess the role of …
(DCVCO) on renal function in vivo and in vitro were investigated to assess the role of …
[HTML][HTML] Cysteine conjugate S-oxidase. Characterization of a novel enzymatic activity in rat hepatic and renal microsomes.
PJ Sausen, AA Elfarra - Journal of Biological Chemistry, 1990 - Elsevier
Cysteine conjugate S-oxidase activity, with S-benzyl-L-cysteine as substrate, was found mostly
in the microsomal fractions of rat liver and kidney. In the presence of oxygen and NADPH, …
in the microsomal fractions of rat liver and kidney. In the presence of oxygen and NADPH, …
Rat 17 beta-hydroxysteroid dehydrogenase type IV is a novel peroxisome proliferator-inducible gene.
…, ES Moreno, A Merritt, DS Marsman, PJ Sausen… - Molecular …, 1996 - ASPET
To better understand the molecular mechanisms of the pleiotropic responses induced by
exposure to peroxisome proliferator chemicals (PPCs), we conducted a systematic search for …
exposure to peroxisome proliferator chemicals (PPCs), we conducted a systematic search for …
Reactivity of cysteine S-conjugate sulfoxides: formation of S-[1-chloro-2-(S-glutathionyl) vinyl]-L-cysteine sulfoxide by the reaction of S-(1, 2-dichlorovinyl)-L-cysteine …
PJ Sausen, AA Elfarra - Chemical research in toxicology, 1991 - ACS Publications
S-(1, 2-Dichlorovinyl)-L-cysteine (DCVC) sulfoxide, a putative metabolite of the toxic cysteine
S-conjugate DCVC, was synthesized by the reaction of DCVC with H202 and characterized …
S-conjugate DCVC, was synthesized by the reaction of DCVC with H202 and characterized …
Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil
…, KM Ferguson, CA Strnat, PJ Sausen - European journal of …, 2004 - Elsevier
Compounds that inhibit phosphodiesterase 5 (PDE5) have been developed for the treatment
of erectile dysfunction. Because men with erectile dysfunction frequently have comorbid …
of erectile dysfunction. Because men with erectile dysfunction frequently have comorbid …
Characterization of the MethionineS-Oxidase Activity of Rat Liver and Kidney Microsomes: Immunochemical and Kinetic Evidence for FMO3 Being the Major Catalyst
RJ Krause, SL Ripp, PJ Sausen, LH Overby… - Archives of biochemistry …, 1996 - Elsevier
Methionine is oxidized to methionine sulfoxide by rat liver and kidney microsomes in an O 2
- and NADPH-dependent manner. In all microsomal assays, no methionine sulfone was …
- and NADPH-dependent manner. In all microsomal assays, no methionine sulfone was …
Further characterization and purification of the flavin-dependent S-benzyl-L-cysteine S-oxidase activities of rat liver and kidney microsomes.
PJ Sausen, RJ Duescher, AA Elfarra - Molecular pharmacology, 1993 - ASPET
Previously, we provided evidence that cysteine conjugate S-oxidase (S-oxidase) activities of
rat liver and kidney microsomes may be associated with flavin-containing monooxygenases …
rat liver and kidney microsomes may be associated with flavin-containing monooxygenases …
Methimazole protection of rats against chemically induced kidney damage in vivo.
PJ Sausen, AA Elfarra, AJ Cooley - Journal of Pharmacology and …, 1992 - ASPET
Because methimazole has antioxidant properties, the effects of methimazole treatment on
cephaloridine, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), 2-bromohydroquinone (2-BHQ) and …
cephaloridine, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), 2-bromohydroquinone (2-BHQ) and …
Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterations
PJ Sausen, DC Lee, ML Rose, RC Cattley - Carcinogenesis, 1995 - academic.oup.com
Recent studies have indicated a lack of correlation between hepatic 8-hydroxy-2′-deoxyguanosine
(8-OHdG) levels and the carcinogenicity of peroxisome proliferators (PP) and …
(8-OHdG) levels and the carcinogenicity of peroxisome proliferators (PP) and …
Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats
PJ Sausen, VJ Teets, KS Voss, RT Miller, RC Cattley - Cancer letters, 1995 - Elsevier
Gemfibrozil is a widely used hypolipidemic drug in humans that causes peroxisome
proliferation and hepatocarcinogenesis in rodents. The induction of hepatomegaly and hepatic …
proliferation and hepatocarcinogenesis in rodents. The induction of hepatomegaly and hepatic …