The time course and intensity of brain hydroxyl radical ( • OH) generation were examined in
male CF‐1 mice during the first hour after moderate or severe concussive head injury. …

Oxygen radical-mediated lipid peroxidation (LP) has been suggested increasingly to be an
important factor in posttraumatic neuronal degeneration. Thus, numerous studies have …

✓ The ability of a novel non-glucocorticoid 21-aminosteroid U74006F to inhibit lipid peroxidation
of central nervous system tissue in vitro and to enhance the early neurological recovery …

U-78517F (2-[4-[2,6-di-(1-pyrrolidinyl)-4-pyridinyl)-1-piperazinyl] methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol,
dihydrochloride), which combines the antioxidant ring …

In the present study, the ability of U74006F, the 21-aminosteroid inhibitor of lipid peroxidation,
to attenuate posttraumatic spinal cord ischemia has been examined in cats following a …

Methods In vivo studies. Male CF-i mice (20-22 g) received daily sc injections of either MP (30
mg/kg/day) or U74006F(30 or 100 mg/kg/day) for 4 days. Mice had free access to food and …

Prior studies have demonstrated that intensive treatment with high doses of methylprednisolone
(MP) can beneficially affect the acutely injured central nervous system by a variety of …

… PA Yonkers, unpublished observations). Similarly, intensive dosing with vitamin E and
selenium has been found to inhibit the development of posttraumatic spinal cord ischemia but not …

Methylprednisolone (MP) improves motor recovery in spinal cord-injured patients when
administered in a 24 h intensive high dose regimen beginning within 8 h after spinal cord injury (…

… to decline in a progressive fashion (Hall and Yonkers, unpublished observations). This
post-… of global brain ischemia in cats (Hall and Yonkers, in press). Together with the support of …