Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

O Della-Zuana, F Presse, C Ortola, J Duhault… - International journal of …, 2002 - nature.com
AIM: Although melanin-concentrating hormone (MCH) is believed to be an important
regulator of feeding behavior, both its acute and chronic effects on food intake as well as its …

Appetite suppression based on selective inhibition of NPY receptors

S Chamorro, O Della-Zuana, JL Fauchere… - International journal of …, 2002 - nature.com
AIM: The aim of this review is to critically assess available evidence that blockade of the
actions of NPY at one of the five NPY receptor subtypes represents an attractive new drug …

Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs.

NR Levens, O Della-Zuana - Current Opinion in Investigational …, 2003 - europepmc.org
Neuropeptide Y (NPY) is present in the hypothalamus, where it is believed to play a key role
in the control of food intake. Evidence for this assertion has come from studies …

Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade

O Della Zuana, M Sadlo, M Germain… - International journal of …, 2001 - nature.com
INTRODUCTION: The purpose of this study was to test the continuing validity of the
hypothesis that neuropeptide Y (NPY) produced in the brain controls food intake through an …

SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study

T Suply, O Della Zuana, V Audinot, M Rodriguez… - … of Pharmacology and …, 2001 - ASPET
O. Della Zuana, unpublished data). In the present study we tried to determine whether the
effects of MCH on feeding behavior were mediated through the described SLC-1 receptor. We …

A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor

O Della-Zuana, L Revereault… - International journal of …, 2004 - nature.com
AIM: These studies were performed to test the hypothesis that endogenous neuropeptide Y (NPY)
acting on the NPY Y 5 receptor subtype contributes to the control of food intake. The …

Appetite-boosting property of pro-melanin-concentrating hormone131–165 (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance

L Maulon-Feraille, O Della Zuana, T Suply… - … of Pharmacology and …, 2002 - ASPET
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, with a major role in
stimulation of feeding behavior in mammals. MCH signals in the brain occur via two seven-…

[HTML][HTML] Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models

O Della-Zuana, JL Nahon, JA Boutin - Frontiers in Endocrinology, 2012 - frontiersin.org
The compound S38151 is a nanomolar antagonist that acts at the melanin-concentrating
hormone receptor 1 (MCH 1 ). S38151 is more stable than its purely peptide counterpart, …

Serotoninergic receptor subtype in coronary artery smooth muscle from young and atherosclerotic rabbit.

M Félétou, O Dellazuana, J Duhault - Journal of Pharmacology and …, 1994 - ASPET
In rabbits fed with hypercholesterolemic diet the normal coronary vasodilator response to
serotonin is replaced by vasoconstriction sensitive to 5HT2 receptor blockade. These …

S38151 [p-guanidinobenzoyl-[Des-Gly10]-MCH (7-17)] is a potent and selective antagonist at the MCH1 receptor and has anti-feeding properties in vivo

…, O Della Zuana, N Fabry, C Ouvry, O Nosjean… - Peptides, 2009 - Elsevier
Structure–activity relationships studies have established the minimal sequence of melanin-concentrating
hormone (MCH) that retains full agonist potency at the MCH 1 , to be the …