Pharmacology of KB‐R7943: A Na+–Ca2+ exchange inhibitor
MS Amran, N Homma… - Cardiovascular drug …, 2003 - Wiley Online Library
The Na + –Ca 2+ exchange (NCX) system plays a pivotal role in regulating intracellular Ca 2+
concentration in cardiomyocytes, neuronal cells, kidney and a variety of other cells. It …
concentration in cardiomyocytes, neuronal cells, kidney and a variety of other cells. It …
Effects of sodium-calcium exchange inhibitors, KB-R7943 and SEA0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation …
MS Amran, K Hashimoto, N Homma - Journal of Pharmacology and …, 2004 - ASPET
The sodium-calcium exchange (NCX) plays a pivotal role in regulating contractility and electrical
activity in the heart. However, the effects of NCX blockers on ventricular arrhythmias are …
activity in the heart. However, the effects of NCX blockers on ventricular arrhythmias are …
A particle-receptor model for the insulin-induced closure of connexin43 channels
N Homma, JL Alvarado, W Coombs… - Circulation …, 1998 - Am Heart Assoc
Connexin43(Cx43) channels can be regulated by a variety of factors, including low pH i .
Structure/function studies from this laboratory have demonstrated that pH gating follows a …
Structure/function studies from this laboratory have demonstrated that pH gating follows a …
Topics on the Na+/Ca2+ exchanger: involvement of Na+/Ca2+ exchange system in cardiac triggered activity
N Homma, MS Amran, Y Nagasawa… - Journal of …, 2006 - Elsevier
Sodium-calcium exchange (NCX) is one of the major regulators of intracellular Ca 2+
concentration in cardiac myocytes. The bi-directional and electrogenic property of NCX raises a …
concentration in cardiac myocytes. The bi-directional and electrogenic property of NCX raises a …
Ionic mechanisms of the depression of automaticity and conduction in the rabbit atrioventricular node caused by hypoxia or metabolic inhibition and protective action …
M Nishimura, H Tanaka, N Homma… - The American journal of …, 1989 - Elsevier
The effects of hypoxia and a metabolic inhibitor, sodium cyanide (NaCN), on the spontaneous
action potential and membrane current systems were studied in small preparations (0.2 × …
action potential and membrane current systems were studied in small preparations (0.2 × …
Augmentation and subsequent attenuation of Ca2+ current due to lipid peroxidation of the membrane caused by t‐butyl hydroperoxide in the rabbit sinoatrial node
…, M Nishimura, H Tanaka, N Homma… - British journal of …, 1989 - Wiley Online Library
Cellular electrophysiological effects of membrane lipid peroxidation by t‐butyl hydroperoxide
(TBH) were studied in the rabbit sinoatrial (SA) node. Superfusion for 1–5 min with 300 μm …
(TBH) were studied in the rabbit sinoatrial (SA) node. Superfusion for 1–5 min with 300 μm …
Both α1A‐ and α1B‐adrenergic receptor subtypes couple to the transient outward current (ITo) in rat ventricular myocytes
N Homma, A Hirasawa, K Shibata… - British journal of …, 2000 - Wiley Online Library
Regulation of transient outward current (I To ) by α 1 ‐adrenergic (α 1 AR) plays a key role
in cardiac repolarization. α 1 ARs comprise a heterogeneous family; two natively expressed …
in cardiac repolarization. α 1 ARs comprise a heterogeneous family; two natively expressed …
A molecular model for the chemical regulation of connexin43 channels: the “ball-and-chain” hypothesis
M Delmar, K Stergiopoulos, N Homma, G Calero… - Current Topics in …, 1999 - Elsevier
Publisher Summary It is the current view that gap junctions are not only passive conduits of
electrical charge but also dynamic filters that modulate the passage of molecular messages …
electrical charge but also dynamic filters that modulate the passage of molecular messages …
Flow cytometry analysis of α1-adrenoceptor subtypes
A Hirasawa, K Tsumaya, T Awaji, K Shibata, N Homma… - FEBS letters, 1996 - Elsevier
To characterize the α 1 -adrenoceptor subtypes, we developed a flow cytometry method using
the fluorescent ligand BODIPY-FL prazosin and the anti-peptide antibody against the α 1b …
the fluorescent ligand BODIPY-FL prazosin and the anti-peptide antibody against the α 1b …
Electrophysiologic actions of aprindine in rabbit atrioventricular node
H Tanaka, M Nishimura, N Homma, Y Habuchi… - Naunyn-Schmiedeberg's …, 1990 - Springer
Aprindine hydrochloride is a potent antiarrhythmic agent against various atrial and ventricular
tachyarrhythmias. To elucidate its pharmacological actions in the atrioventricular node, …
tachyarrhythmias. To elucidate its pharmacological actions in the atrioventricular node, …