Domino reactions are defined as processes of two or more bond-forming reactions under
identical conditions, in which the subsequent transformation takes place at the functionalities …

The first enantioselective syntheses of the Ipecacuanha alkaloid emetine (1) and the
Alangium alkaloid tubulosine (2) is described employing a domino Knoevenagel/hetero‐Diels–…

Transition-metal-catalyzed reactions are widely used as valuable tools for carbon–carbon
bond formation.[1] Whereas palladium and nickel have classically occupied a central role in …

Hydrogen isotopically labelled compounds are essential diagnostic tools in drug research
and development, as they provide vital information about the biological metabolism of drug …

A palladium-catalyzed, norbornene-mediated ortho-alkylation reaction of aryl iodides with
secondary alkyl halides is described. Intermolecular or intramolecular ortho-alkylation …

The therapeutic success of peptidic GLP-1 receptor agonists for treatment of type 2 diabetes
mellitus (T2DM) motivated our search for orally bioavailable small molecules that can …

The development of novel materials and the search for new bioactive compounds, such as
natural products and analogues, drugs, diagnostics and agrochemicals, in academic and …

The design, synthesis, and structure–activity relationship of 1-phenoxy-2-aminoindanes as
inhibitors of the Na + /H + exchanger type 3 (NHE3) are described based on a hit from high-…

In failing hearts, Na + /Ca 2+ exchanger (NCX) overactivity contributes to Ca 2+ depletion,
leading to contractile dysfunction. Inhibition of NCX is expected to normalize Ca 2+ …

The domino Knoevenagel-hetero-Diels-Alder reaction of the aldehyde rac-8, Meldrum’s acid
2 and enol ether 3 leads to the cycloadduct rac-17 as the main product which in a second …