User profiles for Nidhi Sharda
nidhi shardaBristol Myers Squibb Verified email at bms.com Cited by 46 |
Age-dependent changes in the plasma and brain pharmacokinetics of amyloid-β peptides and insulin
Background: Age is the most common risk factor for Alzheimer’s disease (AD), a
neurodegenerative disorder characterized by the hallmarks of toxic amyloid-ß (Aß) plaques and …
neurodegenerative disorder characterized by the hallmarks of toxic amyloid-ß (Aß) plaques and …
Distinct uptake kinetics of Alzheimer disease amyloid-β 40 and 42 at the blood-brain barrier endothelium
N Sharda, KM Ahlschwede, GL Curran, VJ Lowe… - … of Pharmacology and …, 2021 - ASPET
Blood-brain barrier (BBB) endothelial cells lining the cerebral microvasculature maintain
dynamic equilibrium between soluble amyloid-β (Aβ) levels in the brain and plasma. The BBB …
dynamic equilibrium between soluble amyloid-β (Aβ) levels in the brain and plasma. The BBB …
[PDF][PDF] Effect of concentration of alkaline liquid and curing time on strength and water absorption of geopolymer concrete
…, D Choudhary, N Jain, M Kumar, N Sharda… - ARPN Journal of …, 2008 - academia.edu
In order to address environmental effects associated with Portland cement, there is need to
use other binders to make concrete. An effort in this regard is the development of geopolymer …
use other binders to make concrete. An effort in this regard is the development of geopolymer …
Pharmacokinetics of 40 kDa Polyethylene glycol (PEG) in mice, rats, cynomolgus monkeys and predicted pharmacokinetics in humans
N Sharda, P Khandelwal, L Zhang… - European Journal of …, 2021 - Elsevier
Conjugation with polyethylene glycol (PEG), PEGylation, has been considered a useful tool
to improve drug-like properties of novel small molecules and biologics in drug discovery. …
to improve drug-like properties of novel small molecules and biologics in drug discovery. …
Amyloid-β peptides disrupt interactions between VAMP-2 and SNAP-25 in neuronal cells as determined by FRET/FLIM
Background: Synaptic dysfunction prevalent in Alzheimer’s disease (AD) brain is closely
associated with increased accumulation of amyloid-β (Aβ) peptides in the brain parenchyma. It …
associated with increased accumulation of amyloid-β (Aβ) peptides in the brain parenchyma. It …
Semimechanistic population pharmacokinetic modeling to investigate amyloid beta trafficking and accumulation at the BBB endothelium
Elevated exposure to toxic amyloid beta (Aβ) peptides and consequent blood–brain barrier (BBB)
dysfunction are believed to promote vasculopathy in Alzheimer’s disease (AD). …
dysfunction are believed to promote vasculopathy in Alzheimer’s disease (AD). …
Multifarious approaches to attain sustainable fashion
NL Sharda, M VK Kumar - Nordic Textile Journal, 2012 - diva-portal.org
Fashion is a huge industry and affects environmental, economic and social system in many
ways. Exploitation of resources for ever changing trends in fashion is immense and providing …
ways. Exploitation of resources for ever changing trends in fashion is immense and providing …
Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood–Brain Barrier Endothelium
The blood–brain barrier (BBB) plays a critical role in maintaining the equilibrium between
amyloid beta (Aβ) levels in blood and the brain by regulating Aβ transport. Our previous …
amyloid beta (Aβ) levels in blood and the brain by regulating Aβ transport. Our previous …
Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endothelium
Blood-brain barrier (BBB) is a critical portal regulating the bidirectional transport of amyloid
beta (Aβ) proteins between blood and brain. Disrupted trafficking at the BBB may not only …
beta (Aβ) proteins between blood and brain. Disrupted trafficking at the BBB may not only …
[PDF][PDF] Unexplored treasure of the Garhwal Himalayas: Dye yielding plants for sustainable dyeing
NL Sharda, D Rastogi - J Acad Ind Res, 2013 - jairjp.com
The Bhotiya tribes of Chamoli district residing in the border regions of Garhwal Himalayas
are well known for their traditional expertise in making a range of woolen garments and …
are well known for their traditional expertise in making a range of woolen garments and …