Objective Body fat is an important source of hormones and cytokines (adipokines) that not
only regulate the energy balance, but also regulate the inflammatory and immune responses. …

Although the influence of selective cyclooxygenase (COX)‐2 inhibitors on the proliferation
of colon adenocarcinoma cells have been the subject of much investigation, relatively little …

Background Adipokines are bioactive hormones secreted by adipose tissues. Resistin, an
adipokine, plays important roles in the regulation of insulin resistance and inflammation. …

Objective Adipokines may influence inflammatory and/or immune responses. This study was
undertaken to examine whether adiponectin affects the production of prostaglandin E 2 (…

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to induce apoptosis in a
variety of cell lines. In this study, we examined the effect of NSAIDs on the growth and …

The adipokines are linked not only to metabolic regulation, but also to immune responses.
Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid …

Objectives: Midkine (MK) is involved in cell proliferation, differentiation, migration, and survival.
In this study, we measured serum MK levels in rheumatoid arthritis (RA) and investigated …

Background Extracts of Tripterygium wilfordii Hook F (TWHF), a traditional Chinese herb,
have been reported to show efficacy in patients with rheumatoid arthritis (RA). Since RA is not …

… Sei Muraoka, MD Natsuko Kusunoki, PhD Hiroshi Takahashi, MD, PhD Kazuaki Tsuchiya,
MD, PhD Shinichi Kawai, MD, PhD Please address correspondence and reprint requests to …

Objective The objective of the present study was to investigate Epstein-Barr virus (EBV)
infection as an environmental factor for the development of rheumatoid arthritis (RA). Methods …