[HTML][HTML] Circadian rhythm of blood pressure and the renin–angiotensin system in the kidney
N Ohashi, S Isobe, S Ishigaki, H Yasuda - Hypertension Research, 2017 - nature.com
Activation of the intrarenal renin–angiotensin system (RAS) has a critical role in the
pathophysiology of the circadian rhythm of blood pressure (BP) and renal injury, independent of …
pathophysiology of the circadian rhythm of blood pressure (BP) and renal injury, independent of …
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
…, T Yamamoto, A Togawa, N Ohashi… - Proceedings of the …, 2004 - National Acad Sciences
Overexpression of transforming growth factor β (TGF-β) has been shown to play pathogenic
roles in progression of renal fibrosis, and the severity of tubulointerstitial fibrosis correlates …
roles in progression of renal fibrosis, and the severity of tubulointerstitial fibrosis correlates …
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
…, JH Song, DH Han, S Kim, N Ohashi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. The Klotho gene plays a role in suppressing ageing-related disorders. It is
suggested that activation of renin–angiotensin system (RAS) or oxidative stress suppresses …
suggested that activation of renin–angiotensin system (RAS) or oxidative stress suppresses …
The pivotal role of melatonin in ameliorating chronic kidney disease by suppression of the renin–angiotensin system in the kidney
N Ohashi, S Ishigaki, S Isobe - Hypertension Research, 2019 - nature.com
Melatonin is a hormone produced by the pineal gland, predominantly at night, and plays a
pivotal role in regulating the circadian rhythm as well as a variety of biological functions, …
pivotal role in regulating the circadian rhythm as well as a variety of biological functions, …
Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients
…, R Shenava, A Katsurada, T Saito, N Ohashi… - …, 2009 - Am Heart Assoc
We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index
of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent …
of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent …
Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease
…, T Nakagawa, H Suzuki, N Ohashi… - Journal of the …, 2007 - journals.lww.com
In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in
deterioration of renal function, but it is difficult to measure it. For assessment of the potential of …
deterioration of renal function, but it is difficult to measure it. For assessment of the potential of …
Role of mitochondrial DNA in septic AKI via toll-like receptor 9
N Tsuji, T Tsuji, N Ohashi, A Kato… - Journal of the …, 2016 - journals.lww.com
Toll-like receptor 9 (TLR9) contributes to the development of polymicrobial septic AKI. However,
the mechanisms that activate the TLR9 pathway and cause kidney injury during sepsis …
the mechanisms that activate the TLR9 pathway and cause kidney injury during sepsis …
Adipose Tissue–Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy
…, K Hosoda, A Katsurada, N Ohashi… - American journal of …, 2010 - academic.oup.com
Background The adipose tissue renin–angiotensin system (RAS) has been implicated in the
pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation …
pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation …
Urinary angiotensinogen reflects the activity of intrarenal renin–angiotensin system in patients with IgA nephropathy
A Nishiyama, Y Konishi, N Ohashi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. A potential contribution of local activation of the renin–angiotensin system (RAS)
to the pathogenesis of renal injury has been indicated by evidence for blood pressure-…
to the pathogenesis of renal injury has been indicated by evidence for blood pressure-…
Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases
H Kobori, N Ohashi, A Katsurada, K Miyata… - Journal of the American …, 2008 - Elsevier
We previously reported that urinary excretion rates of angiotensinogen (AGT) provide a
specific index of the activity of the intrarenal renin-angiotensin system in angiotensin II-…
specific index of the activity of the intrarenal renin-angiotensin system in angiotensin II-…