Class II antiarrhythmics or β-blockers are antisympathetic nervous system agents that act by
blocking β-adrenoceptors. Despite their common clinical use, little is known about the effects …

Ion channels are key therapeutic targets; however, existing therapeutic classes have
developmental disadvantages. Small molecule drug discovery has often struggled to deliver both …

Introduction Materials and methods References Discussion Conclusion Page 1 Introduction
Automated patch clamp platforms have become an indispensable tool for increasing throughput …

A substantial (approximately 10-fold) increase in QPatch throughput was achieved in a series
of hERG studies by implementing three strategies: 1. multiple drug applications to each …

172a Monday, March 4, 2019 (venom derived cysteine-rich mini-proteins) inhibitors of Kv1.
3 are being developed as potential drug candidates, but often suffer from manufacturing …

VX-770 (Kalydeco) has been approved for clinical usage in CF patients with several CFTR
mutations. Yet neither the binding site (s) on CFTR of the compound nor its mechanism of …

… Author links open overlay panel Mia Dahl Sørensen a b , Maja Thiele b c , Aleksander Krag
… We greatly acknowledge the laboratory work performed by technicians Naja Leire Lorenzen …

Since January 2017 continuous multi-axis differential optical absorption spectroscopy (MAX-DOAS)
observations have been performed for the first time at Pantnagar (29.03 N, 79.47 E), …

This study examines the relationship between career commitment and employee career
success (objective and subjective success) in middle-level employees working in the service …

There has been a growing focus on preparing children for navigating a future where digital
technologies, such as Machine Learning (ML), are present in both society and personal life. …