With NADPH as the electron donor, rat liver NADPH cytochrome P-450 reductase (NADPH:ferricytochrome
oxidoreductase, EC 1.6.2.4) catalyzes the single-electron reduction of …

… Bachur, N. A General Mechanism for the Biological Activation of Qui none Anticancer …
Goodman, MF, Lee, GM, and Bachur, NR Adriamycin Interactions with T4 DNA Polymerase: Two …

A study designed to correlate clinical and pharmacologic observations was undertaken in 96
patients treated with adriamycin. The basic dosage schedule was 60 mg/m 2 IV q 3 weeks. …

Adriamycin, daunorubicin, and other anthracycline antibiotics dramatically augment electron
flow from NADPH to molecular oxygen in rat liver microsomes and heart sarcosomes. This …

Scientific investigations have established that most xenobiotic aldehydes and ketones are
metabolized substantially if not preferentially in mammalian species through reductive …

Fatty acid amides of ethanol-amine in mammalian tissues. Cookies on CAB Direct Like most
websites we use cookies. This is to ensure that we give you the best experience possible …

… II inhibition, their antihelicase activity is significantly more potent (Bachur et al., 1992,
1993). … cell helicase which was quite active in our system with our M13–17-mer substrate (Bachur …

… The daunorubicin was further purified according to the method of Bachur and Cradock.
Administration. Adriamycin was administered into a running intravenous infusion of physiologic …

We studied the human metabolism of adriamycin by isolating and identifying urinary metabolites
which retain adriamycin's specific fluorescence properties. Metabolites were extracted …

Under anaerobic conditions and with proper electron donors, NADPH-cytochrome P-450
reductase (EC 1.6.2.4) and xanthine oxidase (EC 1.2.3.2) similarly reductively metabolized …