Although phenotypically polarized macrophages are now generally classified into two major
subtypes termed proinflammatory M1 and anti-inflammatory M2 macrophages, a …

The effect of resveratrol on various human cancer cells was investigated with special focus
on apoptotic cell death, in an attempt to further characterize its mechanism of action. There …

Objectives: The calcium sensitizer levosimendan is used in treatment of decompensated heart
failure and may also exhibit anti-inflammatory properties. We examined whether treatment …

Glycemic fluctuations may play a critical role in the pathogenesis of diabetic complications,
such as cardiovascular disease. We investigated whether the oxycarotenoid astaxanthin can …

There is growing evidence that the HMG-CoA reductase inhibitors (statins) provide some of
the beneficial effects that are independent of their lipid-lowering effects. Recent animal …

Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication.
The pathogenesis and underlying mechanisms of septic encephalopathy are not well …

Background Epigenetic programming, dynamically regulated by histone acetylation, may
play a key role in the pathophysiology of sepsis. We examined whether histone deacetylase (…

Direct antitumor effects of bisphosphonates (BPs) have been demonstrated in various cancer
cells in vitro. However, the effective concentrations of BPs are typically much higher than …