Migraine is a debilitating disease that affects almost 15% of the population worldwide and is
the first cause of disability in people under 50 years of age, yet its etiology and …

Triple-resonance NMR experiments were used to assign the 13 C α , 13 C β , 15 N and NH
resonances for all the residues in the denatured state of a destabilized protein L variant in 2 …

We have determined the specificity profile of the homing endonuclease I-AniI and compared
it to the conservation of its host gene. Homing endonucleases are encoded within …

To determine the extent to which protein folding rates and free energy landscapes have
been shaped by natural selection, we have examined the folding kinetics of five proteins …

ALD403 is a genetically engineered, humanized immunoglobulin G1 monoclonal antibody
that inhibits the action of human calcitonin gene-related peptide (CGRP). Clinical trial data …

Long insertions into a loop of a folded host protein are expected to have destabilizing effects
because of the entropic cost associated with loop closure unless the inserted sequence …

Adrenocorticotropic hormone (ACTH) is the primary regulator of adrenal glucocorticoid
production. Elevated levels of ACTH play a critical role in disease progression in several …

As a step toward selecting folded proteins from libraries of randomized sequences, we have
designed a ‘loop entropy reduction’‐based phage‐display method. The basic premise is …

Chemokines play a key role in leukocyte recruitment during inflammation and are implicated
in the pathogenesis of a number of autoimmune diseases. As such, inhibiting chemokine …

To further elucidate the mechanism of action and binding properties of eptinezumab to
calcitonin gene-related peptide (CGRP), X-ray crystallography, computational alanine scanning, …