Antibodies are important tools for experimental research and medical applications. Most
antibodies are composed of two heavy and two light chains. Both chains contribute to the …

T cells express a toxin-related ADP-ribosylating ectoenzyme, ART2. Exposure of mature T
cells to NAD, the substrate for ADP-ribosylation, induces cell death. ART2-catalyzed ADP-…

We isolated the LIP2 gene from the lipolytic yeastYarrowia lipolytica. It was found to encode
a 334-amino-acid precursor protein. The secreted lipase is a 301-amino-acid glycosylated …

The P2X7 receptor (P2X 7 R) is an ATP-gated channel that mediates apoptosis of cells of
the immune system. The capacity of P2X 7 R to form large pores depends on its large …

The human cytomegalovirus encodes a β-chemokine receptor (US28) that is distantly related
to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for …

CD4 + CD25 + FoxP3 + regulatory T cells (T reg cells) play a major role in the control of
immune responses but the factors controlling their homeostasis and function remain poorly …

Extracellular NAD and ATP exert multiple, partially overlapping effects on immune cells.
Catabolism of both nucleotides by extracellular enzymes keeps extracellular concentrations low …

We synthesized a Yarrowia lipolytica strain overproducing lipase for industrial applications
by using long terminal repeat (ζ) of the Y. lipolytica retrotransposon Ylt1 and an allele of …

Mono ADP-ribosyltransferase 2 (ART2) is an ectoenzyme expressed on mouse T lymphocytes,
which catalyze the transfer of ADP-ribose groups from NAD+ onto several target proteins. …

ADP‐ribosylation is a post‐translational modification regulating protein function in which
amino acid‐specific ADP‐ribosyltransferases (ARTs) transfer ADP‐ribose from NAD onto …