Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known.
U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, …

A series of 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs)
were prepared and evaluated as potential nonsteroidal antiinflammatory and analgesic …

With an eye toward the development of novel atypical antipsychotic agents, we have studied
the structure-affinity relationships of,'-di-o-tolylguanidine (DTG, 3) and its congeners at the …

Urotensin-II (U-II), a vasoactive cyclic neuropeptide, was recently identified as the natural
ligand for the G-protein coupled receptor GPR14. The expression pattern of U-II and GPR14 …

Four diarylguanidine derivatives were synthesized. These compounds were found to displace,
at submicromolar concentrations, 3H-labeled 1-[1-(2-thienyl)cyclohexyl]piperidine and (+)-…

We report an expansion of the scope of our initial discovery that 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans
(DHDMBFs) are antiinflammatory and analgesic …

The sigma-type opiate receptor is a distinct binding site in the brain that may mediate some
of the psychotomimetic effects caused by benzomorphan opiates and phencyclidine in …

Background and aim The FOLFOX family of chemotherapy regimens are hampered by the
development of a painful neuropathy. Current clinical treatments are inadequate, and …

Selective inhibitors of the slow component of the cardiac delayed rectifier K + current, I Ks ,
are of interest as novel class III antiarrhythmic agents and as tools for studying the physiologic …

A series of 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs)
were found to be nonsteroidal antiinflammatory and analgesic agents. These compounds …