User profiles for Michael P. Hefferan
Michael P. HefferanAssociate Director, Voyager Therapeutics Verified email at vygr.com Cited by 3534 |
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
…, C Bardy, SM Reyna, Y Mu, C Herrera, MP Hefferan… - Nature, 2012 - nature.com
Our understanding of Alzheimer’s disease pathogenesis is currently limited by difficulties in
obtaining live neurons from patients and the inability to model the sporadic form of the …
obtaining live neurons from patients and the inability to model the sporadic form of the …
The Rheb–mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord
S Codeluppi, CI Svensson, MP Hefferan… - Journal of …, 2009 - Soc Neuroscience
Astrocytes in the CNS respond to tissue damage by becoming reactive. They migrate,
undergo hypertrophy, and form a glial scar that inhibits axon regeneration. Therefore, limiting …
undergo hypertrophy, and form a glial scar that inhibits axon regeneration. Therefore, limiting …
[HTML][HTML] Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation
MP Hefferan, J Galik, O Kakinohana, G Sekerkova… - 2012 - journals.plos.org
Background Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1)
causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in …
causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in …
Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells
…, S Marsala, K Johe, T Hazel, MP Hefferan… - Neuroscience, 2007 - Elsevier
Transient spinal cord ischemia in humans can lead to the development of permanent
paraplegia with prominent spasticity and rigidity. Histopathological analyses of spinal cords in …
paraplegia with prominent spasticity and rigidity. Histopathological analyses of spinal cords in …
Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis
…, H Khandwala, G Osmond, MP Hefferan - Journal of Pharmacology …, 2001 - ASPET
Tactile allodynia can be modeled in experimental animals by acutely blocking spinal glycine
or GABA A receptors with intrathecal (it) strychnine (STR) or bicuculline (BIC), respectively. …
or GABA A receptors with intrathecal (it) strychnine (STR) or bicuculline (BIC), respectively. …
[HTML][HTML] The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers
…, J Elia, ED O'Connor, RI Paramban, MP Hefferan… - PloS one, 2010 - journals.plos.org
Background Due to the inherent sensitivity of human embryonic stem cells (hESCs) to
manipulations, the recovery and survival of hESCs after fluorescence-activated cell sorting (FACS) …
manipulations, the recovery and survival of hESCs after fluorescence-activated cell sorting (FACS) …
Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs
…, T Kato Jr, T Tadokoro, MP Hefferan… - Science translational …, 2018 - science.org
The use of autologous (or syngeneic) cells derived from induced pluripotent stem cells (iPSCs)
holds great promise for future clinical use in a wide range of diseases and injuries. It is …
holds great promise for future clinical use in a wide range of diseases and injuries. It is …
Pig models of neurodegenerative disorders: Utilization in cell replacement‐based preclinical safety and efficacy studies
…, J Juhasova, J Motlik, MP Hefferan… - Journal of …, 2014 - Wiley Online Library
An important component for successful translation of cell replacement‐based therapies into
clinical practice is the utilization of large animal models to conduct efficacy and/or safety cell …
clinical practice is the utilization of large animal models to conduct efficacy and/or safety cell …
Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs
…, R Navarro, M Santa, MP Hefferan… - Cell …, 2010 - journals.sagepub.com
In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal
grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to …
grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to …
Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery
Amyotrophic lateral sclerosis (ALS) is characterized by loss of both upper and lower motor
neurons. ALS progression is complex and likely due to cellular dysfunction at multiple levels, …
neurons. ALS progression is complex and likely due to cellular dysfunction at multiple levels, …