The “Amyloid Cascade Hypothesis” has dominated the Alzheimer’s disease (AD) field in the
last 25 years. It posits that the increase of amyloid-ß (Aß) is the key event in AD that triggers …

Amyloid-β (Aβ) peptides are produced in high amounts during Alzheimer's disease, causing
synaptic and memory dysfunction. However, they are also released in lower amounts in …

To investigate the possible long-term consequences of gestational exposure to cannabinoids
on cognitive functions, pregnant rats were administered with the CB1 receptor agonist WIN …

Our previous studies have suggested that dopamine and noradrenaline may be coreleased
from noradrenergic nerve terminals in the cerebral cortex. To further clarify this issue, the …

The variations of Acetylcholine (ACh) release in the cerebral cortex and dorsal hippocampus
were monitored by microdialysis during the electroencephalographically recorded sleep-…

Objective: The goal of this study was to investigate the role of endogenous amyloid‐β peptide
(Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a type of synaptic plasticity …

Background Previous studies by our group suggest that extracellular dopamine (DA) and
noradrenaline (NA) may be co-released from noradrenergic nerve terminals in the cerebral …

Epigenetic mechanisms such as post-translational histone modifications are increasingly
recognized for their contribution to gene activation and silencing in the brain. Histone …

Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely
to play a major role in Alzheimer’s disease (AD). The prevailing hypothesis on the disease …

The present study assessed the efficacy of the cannabinoid CB 1 receptor antagonist, SR-141716,
in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (…