Chronic alcohol administration increases gut‐derived endotoxin in the portal blood, which
activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll‐like …

… b ; Li, Xiangli b ; Froh, Matthias b ; Schemmer, Peter b ; Yin, Ming b ; Bunzendaul, Hartwig
c ; Bradford, Blair d ; Lemasters, John J. a … 14 Lehnert M, Froh M, Zhong Z, et al. Glycine …

BACKGROUND/AIMS: B7-H1 (PD-L1) is a B7-family member that binds to programmed
death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in accelerated …

Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated
and they have recently been shown to be a predominant source of free radicals. Several …

Activation of Kupffer cells by gut-derived endotoxin is associated with alcohol-induced liver
injury. Recently, it was shown that CD14-deficient mice are more resistant to endotoxin-…

Cellular responses to endotoxins are enhanced markedly by LPS-binding protein (LBP).
Furthermore, it has been demonstrated that endotoxins and proinflammatory cytokines such as …

Recent studies have demonstrated that glycine blunts the response of Kupffer cells to endotoxin.
Based on pharmacological evidence, it was hypothesized that Kupffer cells and other …

Accumulating evidence indicates that bacteria and bacterial products promote hepatic
fibrogenesis. The activation of hepatic stellate cells (HSC) plays a central role in hepatic fibrosis. …

Background and Aims: Alcohol-induced liver injury is associated with an increase in oxidants
from a variety of possible sources. Therefore, it was hypothesized that increased and …

TNFα, a mediator of hepatotoxicity in several animal models, is elevated in acute and chronic
liver diseases. Therefore, we investigated whether hepatic injury and fibrosis due to bile …