Objective: Sympathetic nervous system activity in the myocardium is increased in patients
with heart failure. However, the in vivo mechanisms responsible for β-adrenoceptor-mediated …

Reactive oxygen species (ROS) participate in cardioprotection of ischemic reperfusion (I/R)
injury via preconditioning mechanisms. Mitochondrial ROS have been shown to play a key …

Reactive oxygen species (ROS) are key mediators in signal transduction of angiotensin II (Ang
II). However, roles of vascular mitochondria, a major intracellular ROS source, in …

It has recently been shown that glomerular mesangial injury is associated with increases in
renal cortical reactive oxygen species (ROS) levels in rats treated chronically with …

Recently, we demonstrated that in rats treated chronically with aldosterone and salt, severe
tubulointerstitial fibrosis is associated with the activation of mitogen-activated protein kinases …

Recent studies have indicated that angiotensin II (Ang II) can stimulate oxidative stress. The
present study was conducted to assess the contribution of oxygen radicals to hypertension …

Treatment with cyclosporine A (CysA), a potent immunosuppressive agent, is associated
with systemic and renal vasoconstriction, leading to hypertension. The present study was …

The relations among hypertensive response, oxidative stress, and mitogen-activated protein
kinase (MAPK) in cardiovascular tissues have not been fully established. We investigated …

Effects of AT 1 receptor blockade on renal injury and mitogen-activated protein activity in
Dahl salt-sensitive rats. Background The mitogen-activated protein kinase (MAPK) cascade is …

The role of adenosine in the regulation of renal hemodynamics and function has been
studied extensively; however, another purine agent, ATP, is also gaining recognition for its …