[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

…, C Tetta, WE Thasler, T Vanhaecke, M Vinken… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

The adverse outcome pathway concept: a pragmatic tool in toxicology

M Vinken - Toxicology, 2013 - Elsevier
Adverse outcome pathways (AOPs) are novel tools in toxicology and human risk assessment
with broad potential. AOPs are designed to provide a clear-cut mechanistic representation …

[HTML][HTML] Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

…, E Testai, J Van Delft, H Van Loveren, M Vinken… - Archives of …, 2011 - Springer
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …

Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures

…, P Papeleu, S Snykers, M Vinken… - Current drug …, 2006 - ingentaconnect.com
Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Connexins and their channels in cell growth and cell death

M Vinken, T Vanhaecke, P Papeleu, S Snykers… - Cellular signalling, 2006 - Elsevier
Direct communication between cells, mediated by gap junctions, is nowadays considered
as an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

Experimental models of liver fibrosis

…, W Andraus, VA Alves, I Leclercq, M Vinken - Archives of …, 2016 - Springer
Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol abuse, …

Adverse outcome pathways: opportunities, limitations and open questions

…, R Hassan, SH Bennekou, A Limonciel, M Vinken… - Archives of …, 2017 - Springer
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

…, M De Bock, E Decrock, M Bol, M Vinken… - Basic research in …, 2013 - Springer
Connexin-43 (Cx43), a predominant cardiac connexin, forms gap junctions (GJs) that facilitate
electrical cell–cell coupling and unapposed/nonjunctional hemichannels that provide a …

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

…, E Ezra, G Levy, M Cohen, M Vinken… - Proceedings of the …, 2016 - National Acad Sciences
Microfluidic organ-on-a-chip technology aims to replace animal toxicity testing, but thus far
has demonstrated few advantages over traditional methods. Mitochondrial dysfunction plays …

[HTML][HTML] Connexin-related signaling in cell death: to live or let die?

E Decrock, M Vinken, E De Vuyst, DV Krysko… - Cell Death & …, 2009 - nature.com
Evidence is accumulating that some forms of cell death, like apoptosis, are not only governed
by the complex interplay between extracellular and intracellular signals but are also …