A novel chymase inhibitor, 4-[1-{[bis-(4-methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac …
S Takai, D Jin, M Sakaguchi, S Katayama… - … of Pharmacology and …, 2003 - ASPET
Previously, we reported that levels of chymase activity and its mRNA in cardiac tissues were
significantly increased along with progression of cardiac fibrosis in cardiomyopathic …
significantly increased along with progression of cardiac fibrosis in cardiomyopathic …
Cutaneous tissue angiotensin–converting enzyme may participate in pathologic scar formation in human skin
K Morihara, S Takai, H Takenaka, M Sakaguchi… - Journal of the American …, 2006 - Elsevier
BACKGROUND: Many studies have shown that up-regulation of angiotensin-converting
enzyme (ACE) participates in adverse fibrous remodeling. Although this has become an …
enzyme (ACE) participates in adverse fibrous remodeling. Although this has become an …
Increased local angiotensin II formation in aneurysmal aorta
…, A Yuda, Y Sawada, M Yamada, D Jin, M Sakaguchi… - Life sciences, 2002 - Elsevier
We investigated the levels and locations of angiotensin II-forming enzymes, angiotensin
converting enzyme (ACE) and chymase, in aneurysmal and normal aortas. Aneurysmal aortic …
converting enzyme (ACE) and chymase, in aneurysmal and normal aortas. Aneurysmal aortic …
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction
D Jin, S Takai, M Yamada, M Sakaguchi… - Cardiovascular …, 2003 - academic.oup.com
Objectives: Recent studies have demonstrated that hamsters, like humans, possess both
angiotensin converting enzyme (ACE)- and chymase-dependent angiotensin (Ang) II-forming …
angiotensin converting enzyme (ACE)- and chymase-dependent angiotensin (Ang) II-forming …
Direct detection of effective glass transitions in miscible polymer blends by temperature-modulated differential scanning calorimetry
Y Miwa, K Usami, K Yamamoto, M Sakaguchi… - …, 2005 - ACS Publications
Individual effective glass transitions of components in miscible blends of polystyrene/poly(vinyl
methyl ether), poly(o-chlorostyrene)/poly(vinyl methyl ether), and poly(styrene-block-n-…
methyl ether), poly(o-chlorostyrene)/poly(vinyl methyl ether), and poly(styrene-block-n-…
Well-defined polystyrene grafted to polypropylene backbone by “living” radical polymerization with TEMPO
Y Miwa, K Yamamoto, M Sakaguchi… - Macromolecules, 2001 - ACS Publications
A stable free radical (2,2,6,6-tertamethylpiperidinyl-1-oxy, TEMPO) polymerization technique
was applied to a graft polymerization of styrene (ST) to polypropylene (PP). PP peroxides …
was applied to a graft polymerization of styrene (ST) to polypropylene (PP). PP peroxides …
ESR evidence for main‐chain scission produced by mechanical fracture of polymers at low temperature
M Sakaguchi, J Sohma - Journal of Polymer Science: Polymer …, 1975 - Wiley Online Library
ESR spectra have been observed from several polymers (polyethylene, polypropylene,
polymethylmethacrylate, polytetrafluoroethylene, and polybutadiene) which were mechanically …
polymethylmethacrylate, polytetrafluoroethylene, and polybutadiene) which were mechanically …
Different angiotensin II-forming pathways in human and rat vascular tissues
S Takai, M Sakaguchi, D Jin, M Yamada, K Kirimura… - Clinica chimica acta, 2001 - Elsevier
We studied the angiotensin II-forming pathways in extracts from human and rat vascular
tissues. In the extract from human artery, angiotensin I mainly converted to two products, …
tissues. In the extract from human artery, angiotensin I mainly converted to two products, …
Chymase-dependent angiotensin II formation in human vascular tissue
S Takai, D Jin, M Sakaguchi, M Miyazaki - Circulation, 1999 - Am Heart Assoc
Background—Some reports have suggested that, in vitro, human heart chymase in homogenates
contributes little to angiotensin (Ang) II formation in the presence of natural protease …
contributes little to angiotensin (Ang) II formation in the presence of natural protease …
Characterization of chymase from human vascular tissues
S Takai, N Shiota, M Sakaguchi, H Muraguchi… - Clinica chimica acta, 1997 - Elsevier
A chymostatin-sensitive angiotensin II-generating enzyme was found in human gastroepiploic
arteries. The enzyme was purified using heparin affinity and gel filtration columns. The …
arteries. The enzyme was purified using heparin affinity and gel filtration columns. The …