We found that 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) is a potent
and selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (…

The forebrain cholinergic system promotes higher brain function in part by signaling through
the M 1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), …

Use-dependent N-methyl-d-aspartate receptor (NMDAR) antagonists produce behaviors in
human volunteers that resemble schizophrenia and exacerbate those behaviors in …

This report describes the discovery of the first centrally active allosteric modulators of the
metabotropic glutamate receptor subtype 5 (mGluR5). Appropriately substituted N-(1,3-diphenyl…

Glycine acts as a necessary coagonist for glutamate at the NMDA receptor (NMDAR) complex
by binding to the strychnine-insensitive glycine-B binding site on the NR1 subunit. The fact …

Design, Synthesis, and In Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived
from a Series of [4-Phenyl-1-(propylsulfonyl) piperidin-4-yl] methyl Benzamides

The complexity of the 5-hydroxytryptamine (5-HT) (serotonin) receptor family has been increased
by the findings that isoforms or splice variants exist for subtypes such as the 5-HT 2B , 5…

A novel, potent nonpeptide oxytocin receptor antagonist (1-(1-(2-(2,2,2-trifluoroethoxy)-4-(1-methylsulfonyl-4-piperidinyloxy)
phenylacetyl)-4-piperidinyl)-3,4-dihydro-2(1H)-quinolinone) …

Background Alzheimer's disease (AD) patients suffer from an inexorable loss of cognitive
function due in part to the degeneration of the basal forebrain cholinergic projection neurons. …

Background In addition to the primary pathological features of extraneuronal amyloid β (Aβ)
protein deposition and intraneuronal aggregation of hyperphosphorylated tau in Alzheimer's …