[HTML][HTML] Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
…, L Vallier, JC Marioni, M Chhatriwala… - Nature …, 2020 - nature.com
Recent developments in stem cell biology have enabled the study of cell fate decisions in
early human development that are impossible to study in vivo. However, understanding how …
early human development that are impossible to study in vivo. However, understanding how …
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
The genomic regulatory programmes that underlie human organogenesis are poorly
understood. Pancreas development, in particular, has pivotal implications for pancreatic …
understood. Pancreas development, in particular, has pivotal implications for pancreatic …
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation
MK Chhatriwala, L Betts, DK Worthylake… - Journal of molecular …, 2007 - Elsevier
Rho-family GTPases are activated by the exchange of bound GDP for GTP, a process that is
catalyzed by Dbl-family guanine nucleotide exchange factors (GEFs). The catalytic unit of …
catalyzed by Dbl-family guanine nucleotide exchange factors (GEFs). The catalytic unit of …
Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an …
M Chhatriwala, RG Ravi, RI Patel, JL Boyer… - … of Pharmacology and …, 2004 - ASPET
ADP is the cognate agonist of the P2Y 1 , P2Y 12 , and P2Y 13 receptors. With the goal of
identifying a high potency agonist that selectively activates the P2Y 1 receptor, we examined …
identifying a high potency agonist that selectively activates the P2Y 1 receptor, we examined …
[HTML][HTML] Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity
Background Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases
the effective number of functionally distinct gene products. Using bulk RNA sequencing, …
the effective number of functionally distinct gene products. Using bulk RNA sequencing, …
[PDF][PDF] Laser capture and deep sequencing reveals the transcriptomic programmes regulating the onset of pancreas and liver differentiation in human embryos
…, SJ Wearne, J Strutt, S Withey, M Chhatriwala… - Stem Cell Reports, 2017 - cell.com
To interrogate the alternative fates of pancreas and liver in the earliest stages of human
organogenesis, we developed laser capture, RNA amplification, and computational analysis of …
organogenesis, we developed laser capture, RNA amplification, and computational analysis of …
[PDF][PDF] GATA6 cooperates with EOMES/SMAD2/3 to deploy the gene regulatory network governing human definitive endoderm and pancreas formation
…, J Garcia-Bernardo, R El-Khairi, M Chhatriwala… - Stem cell reports, 2019 - cell.com
Heterozygous de novo mutations in GATA6 are the most frequent cause of pancreatic agenesis
in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and …
in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and …
Generation of functional hepatocytes by forward programming with nuclear receptors
…, I Geti, CP Segeritz, MC de Brito, M Chhatriwala… - Elife, 2022 - elifesciences.org
Production of large quantities of hepatocytes remains a major challenge for a number of
clinical applications in the biomedical field. Directed differentiation of human pluripotent stem …
clinical applications in the biomedical field. Directed differentiation of human pluripotent stem …
KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules
…, S Cipolat, LM Sevilla, M Chhatriwala… - Journal of cell …, 2009 - journals.biologists.com
Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the
cytolinker protein periplakin. Multiple functions of kazrin have been reported, including …
cytolinker protein periplakin. Multiple functions of kazrin have been reported, including …
[PDF][PDF] Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program
…, D Muraro, P Madrigal, K Tilgner, M Chhatriwala… - Stem Cell Reports, 2021 - cell.com
Heterozygous mutations in HNF1B in humans result in a multisystem disorder, including
pancreatic hypoplasia and diabetes mellitus. Here we used a well-controlled human induced …
pancreatic hypoplasia and diabetes mellitus. Here we used a well-controlled human induced …