Recent developments in stem cell biology have enabled the study of cell fate decisions in
early human development that are impossible to study in vivo. However, understanding how …

The genomic regulatory programmes that underlie human organogenesis are poorly
understood. Pancreas development, in particular, has pivotal implications for pancreatic …

Rho-family GTPases are activated by the exchange of bound GDP for GTP, a process that is
catalyzed by Dbl-family guanine nucleotide exchange factors (GEFs). The catalytic unit of …

ADP is the cognate agonist of the P2Y 1 , P2Y 12 , and P2Y 13 receptors. With the goal of
identifying a high potency agonist that selectively activates the P2Y 1 receptor, we examined …

Background Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases
the effective number of functionally distinct gene products. Using bulk RNA sequencing, …

To interrogate the alternative fates of pancreas and liver in the earliest stages of human
organogenesis, we developed laser capture, RNA amplification, and computational analysis of …

Heterozygous de novo mutations in GATA6 are the most frequent cause of pancreatic agenesis
in humans. In mice, however, a similar phenotype requires the biallelic loss of Gata6 and …

Production of large quantities of hepatocytes remains a major challenge for a number of
clinical applications in the biomedical field. Directed differentiation of human pluripotent stem …

Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the
cytolinker protein periplakin. Multiple functions of kazrin have been reported, including …

Heterozygous mutations in HNF1B in humans result in a multisystem disorder, including
pancreatic hypoplasia and diabetes mellitus. Here we used a well-controlled human induced …