[HTML][HTML] DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke
…, W Zhang, MM Soundarapandian, C Belal, M Wang… - Cell, 2010 - cell.com
N-methyl-D-aspartate (NMDA) receptors constitute a major subtype of glutamate receptors
at extrasynaptic sites that link multiple intracellular catabolic processes responsible for …
at extrasynaptic sites that link multiple intracellular catabolic processes responsible for …
[PDF][PDF] ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia
PL Peng, X Zhong, W Tu, MM Soundarapandian… - Neuron, 2006 - cell.com
ADAR2 is a nuclear enzyme essential for GluR2 pre-mRNA editing at Q/R site-607, which
gates Ca 2+ entry through AMPA receptor channels. Here, we show that forebrain ischemia in …
gates Ca 2+ entry through AMPA receptor channels. Here, we show that forebrain ischemia in …
Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
GA Kyriazis, MM Soundarapandian… - Proceedings of the …, 2012 - National Acad Sciences
Postprandial insulin release is regulated by glucose, but other circulating nutrients may
target beta cells and potentiate glucose-stimulated insulin secretion via distinct signaling …
target beta cells and potentiate glucose-stimulated insulin secretion via distinct signaling …
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth
OJ Martin, L Lai, MM Soundarapandian… - Circulation …, 2014 - Am Heart Assoc
Rationale: Increasing evidence has shown that proper control of mitochondrial dynamics (fusion
and fission) is required for high-capacity ATP production in the heart. Transcriptional …
and fission) is required for high-capacity ATP production in the heart. Transcriptional …
[HTML][HTML] Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death
L Cilenti, MM Soundarapandian, GA Kyriazis… - Journal of Biological …, 2004 - ASBMB
Omi/HtrA2 is a nuclear-encoded mitochondrial serine protease that has a pro-apoptotic function
in mammalian cells. Upon induction of apoptosis, Omi translocates to the cytoplasm and …
in mammalian cells. Upon induction of apoptosis, Omi translocates to the cytoplasm and …
LDL-cholesterol reduction by ANGPTL3 inhibition in mice is dependent on endothelial lipase
L Wu, MM Soundarapandian, AB Castoreno… - Circulation …, 2020 - Am Heart Assoc
Humans carrying ANGPTL3 loss-of-function mutations have reduced plasma TG (triglyceride),
LDL-C (lowdensity lipoprotein cholesterol), and HDL-C (high-density lipoprotein …
LDL-C (lowdensity lipoprotein cholesterol), and HDL-C (high-density lipoprotein …
[HTML][HTML] MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
B Ahn, MM Soundarapandian… - The Journal of …, 2016 - Am Soc Clin Investig
Intramuscular lipid accumulation is a common manifestation of chronic caloric excess and
obesity that is strongly associated with insulin resistance. The mechanistic links between lipid …
obesity that is strongly associated with insulin resistance. The mechanistic links between lipid …
[HTML][HTML] Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination
MM Soundarapandian, V Selvaraj, UG Lo, MS Golub… - Scientific reports, 2011 - nature.com
Basic helix-loop-helix transcription factors Olig1 and Olig2 critically regulate oligodendrocyte
development. Initially identified as a downstream effector of Olig1, an oligodendrocyte-…
development. Initially identified as a downstream effector of Olig1, an oligodendrocyte-…
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells
…, GA Kyriazis, MM Soundarapandian… - American Journal …, 2005 - journals.physiology.org
Omi/HtrA2 is a mitochondrial proapoptotic serine protease that is able to induce both
caspase-dependent and caspase-independent cell death. After apoptotic stimuli, Omi is released to …
caspase-dependent and caspase-independent cell death. After apoptotic stimuli, Omi is released to …
Role of KATP channels in protection against neuronal excitatory insults
MM Soundarapandian, X Zhong, L Peng… - Journal of …, 2007 - Wiley Online Library
ATP‐sensitive K + (K ATP ) channels that are gated by intracellular ATP/ADP concentrations
are a unique subtype of potassium channels and play an essential role in coupling …
are a unique subtype of potassium channels and play an essential role in coupling …