Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
P Kuehl, J Zhang, Y Lin, J Lamba, M Assem… - Nature …, 2001 - nature.com
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …
Glioblastoma genomics: a very complicated story
MY Lombardi, M Assem - Exon Publications, 2017 - exonpublications.com
Glioblastoma is a deadly disease that has not shown improvement despite the development
of new diagnostic tools and innovative targeted therapies. This grim outcome is mainly …
of new diagnostic tools and innovative targeted therapies. This grim outcome is mainly …
[HTML][HTML] Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
…, S Strom, K Yasuda, V Lecureur, M Assem… - Journal of Biological …, 2001 - ASBMB
Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP). BSEP/SPGP
expression varies dramatically among human livers. The potency and hierarchy of bile …
expression varies dramatically among human livers. The potency and hierarchy of bile …
[HTML][HTML] Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia
C Zhou, M Assem, JC Tay, PB Watkins… - The Journal of …, 2006 - Am Soc Clin Investig
The balance between bioactivation and degradation of 1,25-dihydroxyvitamin D 3 [1,25(OH)
2 D 3 ] is critical for ensuring appropriate biological effects of vitamin D. Cytochrome P450, …
2 D 3 ] is critical for ensuring appropriate biological effects of vitamin D. Cytochrome P450, …
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
V Lamba, K Yasuda, JK Lamba, M Assem… - Toxicology and applied …, 2004 - Elsevier
To gain insight on the expression of pregnane X receptor (PXR), we analyzed PXR.1 and
PXR alternatively spliced transcripts in a panel of 36 human tissues. PXR.1 was expressed in …
PXR alternatively spliced transcripts in a panel of 36 human tissues. PXR.1 was expressed in …
[HTML][HTML] Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
M Assem, EG Schuetz, M Leggas, D Sun… - Journal of Biological …, 2004 - ASBMB
The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids
interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under …
interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under …
Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences
JK Lamba, V Lamba, K Yasuda, YS Lin, M Assem… - … of Pharmacology and …, 2004 - ASPET
The constitutive androstane receptor (CAR) NR1I3 is a transcription factor that upon activation
by xenobiotics induces transcription of drug-metabolizing and drug transporter genes. Our …
by xenobiotics induces transcription of drug-metabolizing and drug transporter genes. Our …
Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia
…, M Zeller, C Vergely, A Laubriet, M Assem… - Journal of …, 1999 - journals.lww.com
Formation of oxygen free radicals during heart transplantation seems to be related to the
alterations occurring during ischemia and reperfusion and could explain the short preservation …
alterations occurring during ischemia and reperfusion and could explain the short preservation …
Inconstant Association between 27‐kDa Heat‐Shock Protein (Hsp27) Content and Doxorubicin Resistance in Human Colon Cancer Cells: The Doxorubicin …
…, A Fromentin, A Hammann, M Assem… - European Journal of …, 1996 - Wiley Online Library
To investigate the role of the small 27‐kDa heat‐shock protein (Hsp27) in the intrinsic resistance
of colon cancer cells to doxorubicin, we modified Hsp27 expression either genetically …
of colon cancer cells to doxorubicin, we modified Hsp27 expression either genetically …
The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia
Background Glucocorticoids are used in the curative treatment of acute lymphoblastic leukemia
(ALL). Resistance to glucocorticoids is an important adverse prognostic factor in newly …
(ALL). Resistance to glucocorticoids is an important adverse prognostic factor in newly …