[PDF][PDF] Molecular pharmacology, regulation and function of mammalian melatonin receptors

ML Dubocovich, MA Rivera-Bermudez, MJ Gerdin… - Front …, 2003 - article.imrpress.com
… Mseeh F., MJ Gerdin and MI Dubocovich: Identification of cysteines involved in ligand
binding to the human melatonin MT2 receptor. Eur J Pharmacol 449, 2938 (2002) …

Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian …

MJ Gerdin, MI Masana… - The FASEB …, 2004 - Wiley Online Library
The hormone melatonin phase shifts circadian rhythms generated by the mammalian biological
clock, the suprachiasmatic nucleus (SCN) of the hypothalamus, through activation of G …

Regulation of PC12 cell differentiation by cAMP signaling to ERK independent of PKA: do all the connections add up?

MJ Gerdin, LE Eiden - Science's STKE, 2007 - science.org
Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide that elevates
adenosine 3′,5′-monophosphate (cyclic AMP, also abbreviated cAMP) to elicit …

Melatonin-mediated regulation of human MT1 melatonin receptors expressed in mammalian cells

MJ Gerdin, MI Masana, ML Dubocovich - Biochemical pharmacology, 2004 - Elsevier
In mammals, the pineal hormone melatonin activates G protein-coupled MT 1 and MT 2
melatonin receptors. Acute exposure of recombinant MT 1 and MT 2 melatonin receptors to …

A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells

A Ravni, D Vaudry, MJ Gerdin, MV Eiden… - Molecular …, 2008 - ASPET
… We are currently investigating this possibility, and have observed cAMP-dependent, H89-resistant
ERK activation in bovine chromaffin cells (MJ Gerdin, unpublished observations). …

Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors

MJ Gerdin, MI Masana, D Ren, RJ Miller… - … of Pharmacology and …, 2003 - ASPET
The hormone melatonin mediates a variety of physiological functions in mammals through
activation of pharmacologically distinct MT 1 and MT 2 G protein-coupled melatonin receptors. …

Mutagenesis studies of the human MT2 melatonin receptor

MJ Gerdin, F Mseeh, ML Dubocovich - Biochemical pharmacology, 2003 - Elsevier
Melatonin mediates its physiological effects through activation of high affinity G protein-coupled
receptors. The vertebrate MT 1 , MT 2 and Mel 1c melatonin receptors are molecularly …

Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells

MA Rivera-Bermúdez, MJ Gerdin, DJ Earnest… - Neuroscience …, 2003 - Elsevier
Melatonin phase shifts circadian rhythms of the neuronal firing rate and stimulates PKC
activity at dusk (CT 10) and dawn (CT 23) in the rat suprachiasmatic nucleus (SCN) slice via …

Discovery of Pituitary Adenylate Cyclase‐Activating Polypeptide‐Regulated Genes through Microarray Analyses in Cell Culture and In Vivo

LE Eiden, B Samal, MJ Gerdin… - Annals of the New …, 2008 - Wiley Online Library
Pituitary adenylate cyclase‐activating polypeptide (PACAP) is an evolutionarily well conserved
neuropeptide with multiple functions in the nervous, endocrine, and immune systems. …

Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP …

B Samal, MJ Gerdin, D Huddleston, CM Hsu… - Peptides, 2007 - Elsevier
Initial PACAP-regulated transcriptomes of PACAP-treated cultured chromaffin cells, and the
adrenal gland of wild-type versus PACAP-deficient mice, have been assembled using …