Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and α-OH-midazolam

B Tuk, MF Van Oostenbruggen, VMM Herben… - … of Pharmacology and …, 1999 - ASPET
The pharmacodynamic interaction between midazolam and its active metabolite α-OH-midazolam
was investigated to evaluate whether estimates of relevant pharmacodynamic …

Penny and pound wise: pharmacoeconomics from a governmental perspective

MF van Oostenbruggen, RB Jansen, K Mur… - …, 2005 - Springer
Because of growing pressure on the healthcare budget in The Netherlands, appropriate
justification of current expenditures and future investments in public healthcare are becoming …

Integrated pharmacokinetics and pharmacodynamics of Ro 48–6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male …

…, JJL Oberyé, MF Van Oostenbruggen… - British journal of …, 1997 - Wiley Online Library
Aims This study was performed to investigate the pharmacokinetics and pharmacodynamics
of ascending doses of Ro 48–6791, compared with midazolam, in healthy subjects during …

Solving inconsistencies in the analysis of receptor-ligand interactions.

B Tuk, MF Van Oostenbruggen - Trends in pharmacological …, 1996 - europepmc.org
… Here, Bertil Tuk and Michael van Oostenbruggen re-examine the derivation of the model
and pinpoint the origin of the observed inconsistencies, thereby demonstrating that these …

[HTML][HTML] Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis

…, RJ van Oostenbrugge, MPJ van Boxtel… - PloS one, 2017 - journals.plos.org
Aims/Hypothesis Accumulating evidence suggests an association between coronary heart
disease and risk for cognitive impairment or dementia, but no study has systematically …

Cerebral hyperperfusion syndrome

…, GW Schurink, RJ van Oostenbrugge… - The Lancet …, 2005 - thelancet.com
Cerebral hyperperfusion syndrome (CHS) after carotid endarterectomy is characterised by
ipsilateral headache, hypertension, seizures, and focal neurological deficits. If not treated …

Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded …

…, RJ van Oostenbrugge, A van der Lugt… - The Lancet …, 2022 - thelancet.com
Background Pooled analyses of previous randomised studies have suggested that very early
treatment with glyceryl trinitrate (also known as nitroglycerin) improves functional outcome …

Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients

LHG Henskens, AA Kroon, RJ Van Oostenbrugge… - …, 2008 - Am Heart Assoc
Aortic stiffness predicts an excess risk of stroke, supposedly via cerebral small-vessel
disease. White matter hyperintensities, silent lacunar infarcts, and brain microbleeds, …

The missing link in the pathophysiology of vascular cognitive impairment: design of the heart-brain study

…, RJ van Oostenbrugge, MJP van Osch… - Cerebrovascular …, 2018 - karger.com
Background: Hemodynamic balance in the heart-brain axis is increasingly recognized as a
crucial factor in maintaining functional and structural integrity of the brain and thereby …

The role of dual energy CT in differentiating between brain haemorrhage and contrast medium after mechanical revascularisation in acute ischaemic stroke

…, W Van Zwam, R De Graaf, RJ Van Oostenbrugge… - European …, 2014 - Springer
Objectives To assess the feasibility of dual energy computed tomography (DE-CT) in intra-arterially
treated acute ischaemic stroke patients to discriminate between contrast …