Transforming growth factor-β in normal nociceptive processing and pathological pain models
A Lantero, M Tramullas, A Díaz, MA Hurlé - Molecular neurobiology, 2012 - Springer
The transforming growth factor-β (TGF-β) superfamily is a multifunctional, contextually acting
family of cytokines that participate in the regulation of development, disease and tissue …
family of cytokines that participate in the regulation of development, disease and tissue …
Extracellular heat shock protein 90 binding to TGFβ receptor I participates in TGFβ-mediated collagen production in myocardial fibroblasts
R García, D Merino, JM Gómez, JF Nistal, MA Hurlé… - Cellular signalling, 2016 - Elsevier
The pathological remodeling heart shows an increase in left ventricular mass and an excess
of extracellular matrix deposition that can over time cause heart failure. Transforming …
of extracellular matrix deposition that can over time cause heart failure. Transforming …
Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients
…, M Cobo, C Montalvo, R Martín-Durán, MA Hurlé… - International journal of …, 2013 - Elsevier
Background Various human cardiovascular pathophysiological conditions associate aberrant
expression of microRNAs (miRNAs) and circulating miRNAs are emerging as promising …
expression of microRNAs (miRNAs) and circulating miRNAs are emerging as promising …
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome
…, AM Briones, R Alberca, N Lozano-Vidal, MA Hurlé… - Nature medicine, 2017 - nature.com
Heritable thoracic aortic aneurysms and dissections (TAAD), including Marfan syndrome (MFS),
currently lack a cure, and causative mutations have been identified for only a fraction of …
currently lack a cure, and causative mutations have been identified for only a fraction of …
[HTML][HTML] Plasma levels of transforming growth factor-β1 reflect left ventricular remodeling in aortic stenosis
…, F Gonzalez-Vilchez, R Martin-Duran, MA Hurle… - PLoS …, 2009 - journals.plos.org
Background TGF-β1 is involved in cardiac remodeling through an auto/paracrine mechanism.
The contribution of TGF-β1 from plasmatic source to pressure overload myocardial …
The contribution of TGF-β1 from plasmatic source to pressure overload myocardial …
Gender differences of echocardiographic and gene expression patterns in human pressure overload left ventricular hypertrophy
…, R Merino, R Martín-Durán, MA Hurlé… - Journal of molecular and …, 2009 - Elsevier
Gender influence on left ventricular (LV) remodeling associated to aortic valve stenosis (AS)
has been long recognized, but underlying myocardial gene expression patterns have not …
has been long recognized, but underlying myocardial gene expression patterns have not …
BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-β family in pain modulation
…, JM Hurlé, JC Izpisúa-Belmonte, MA Hurlé - Journal of …, 2010 - Soc Neuroscience
Transforming growth factors-β (TGF-βs) signal through type I and type II serine–threonine
kinase receptor complexes. During ligand binding, type II receptors recruit and phosphorylate …
kinase receptor complexes. During ligand binding, type II receptors recruit and phosphorylate …
[HTML][HTML] BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling
…, A Lantero, M Tramullas, JM Hurlé, MA Hurle… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Left ventricular (LV) pressure overload is a major cause of heart failure. Transforming growth
factors-β (TGF-βs) promote LV remodeling under biomechanical stress. BAMBI (BMP and …
factors-β (TGF-βs) promote LV remodeling under biomechanical stress. BAMBI (BMP and …
[HTML][HTML] Androgens contribute to sex differences in myocardial remodeling under pressure overload by a mechanism involving TGF-β
…, R Garcia, M Ares, M Llano, M Cobo, MA Hurle… - PloS one, 2012 - journals.plos.org
Background In clinical studies, myocardial remodeling in aortic valve stenosis appears to be
more favorable in women than in men, even after menopause. In the present study, we …
more favorable in women than in men, even after menopause. In the present study, we …
BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery
…, S Cabezudo, JF Nistal, MA Hurlé - Cardiovascular …, 2016 - academic.oup.com
Aims TGF-β regulates tissue fibrosis: TGF-β promotes fibrosis, whereas bone morphogenetic
protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after …
protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after …