N-(fluorenyl-9-methoxycarbonyl) amino acids, a class of antiinflammatory agents with a different mechanism of action.
RM Burch, M Weitzberg, N Blok… - Proceedings of the …, 1991 - National Acad Sciences
Several members of a series of N-(fluorenyl-9-methoxycarbonyl) amino acids were found to
possess a broad spectrum of antiinflammatory activity. The compounds were active against …
possess a broad spectrum of antiinflammatory activity. The compounds were active against …
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N …
…, A Geyer, W McClellan, M Weitzberg… - Journal of medicinal …, 2004 - ACS Publications
The preparation and assessment of biological activity of 6-substituted 2-naphthamidine
inhibitors of the serine protease urokinase plasminogen activator (uPA, or urokinase) is …
inhibitors of the serine protease urokinase plasminogen activator (uPA, or urokinase) is …
[PDF][PDF] Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite
…, K Stewart, K Walter, J Wang, M Wendt, M Weitzberg… - Structure, 2000 - cell.com
Background: Human urokinase-type plasminogen activator has been implicated in the
regulation and control of basement membrane and interstitial protein degradation. Because of its …
regulation and control of basement membrane and interstitial protein degradation. Because of its …
Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA …
YG Gu, M Weitzberg, RF Clark, X Xu, Q Li… - Journal of medicinal …, 2006 - ACS Publications
A structurally novel acetyl-CoA carboxylase (ACC) inhibitor is identified from high-throughput
screening. A preliminary structure−activity relationship study led to the discovery of potent …
screening. A preliminary structure−activity relationship study led to the discovery of potent …
Asymmetric michael additions of ester enolates to enantiomerically pure vinylic sulfoxides: synthesis of 3-substituted glutarate esters in high enantiomeric purity
GH Posner, M Weitzberg, TG Hamill, E Asirvatham… - Tetrahedron, 1986 - Elsevier
… The hexamethyldisihuane and dimethyl formamide (DMF) were distilled from CaH,, and the
m… 3H)f’mass spectrum m/z 156 (M’).-Kugelrohr distillation gave 70 mg of a colorless liquid : […
m… 3H)f’mass spectrum m/z 156 (M’).-Kugelrohr distillation gave 70 mg of a colorless liquid : […
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties
…, A Geyer, CR Dalton, MA Kaminski, M Weitzberg… - Bioorganic & medicinal …, 2005 - Elsevier
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator
(uPA) inhibitors are described. These compounds possess excellent binding activities and …
(uPA) inhibitors are described. These compounds possess excellent binding activities and …
Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6, 8-disubstituted 2-naphthamidine urokinase inhibitors
…, WJ McClellan, TW Rockway, M Weitzberg… - Bioorganic & medicinal …, 2004 - Elsevier
Several 8-substituted 2-naphthamidine-based inhibitors of the serine protease urokinase
plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or …
plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or …
N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and …
YG Gu, M Weitzberg, RF Clark, X Xu, Q Li… - Journal of medicinal …, 2007 - ACS Publications
A preliminary safety evaluation of ACC2 inhibitor 1-(S) revealed serious neurological and
cardiovascular liabilities of this chemotype. A systematic structure−toxicity relationship study …
cardiovascular liabilities of this chemotype. A systematic structure−toxicity relationship study …
Species specificity of amidine-based urokinase inhibitors
…, S Dorwin, P Richardson, M Weitzberg, M Wendt… - Biochemistry, 2001 - ACS Publications
… K i values were calculated using the previously established K m values for S-2444: 55 μM
… Microtiter plates were precoated with 50 μL/well of 20 μg/mL human fibronectin in 0.1 M …
… Microtiter plates were precoated with 50 μL/well of 20 μg/mL human fibronectin in 0.1 M …
Novel antibacterial class
…, EE Englund, R Wagner, M Weitzberg… - Antimicrobial agents …, 2003 - Am Soc Microbiol
We report the discovery and characterization of a novel ribosome inhibitor (NRI) class that
exhibits selective and broad-spectrum antibacterial activity. Compounds in this class inhibit …
exhibits selective and broad-spectrum antibacterial activity. Compounds in this class inhibit …