The effects on sleep of N6-L-(phenylisopropyl) adenosine, cyclohexyladenosine and
adenosine-5'-ethylcarboxamide were studied in rats. Also, the effects on sleep of deoxycoformycin, …

The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-59-N-ethylcarboxamide
on sleep were examined in rats. These effects consist of 1) increased …

We have examined the effects on sleep and brain temperature of bilateral microinjections of
adenosine and adenosine analogs to the preoptic area (PO) of rats. Administration of …

… Radulovacki have received additional research support from NV Organon and BTG …
Radulovacki are named inventors of a technology for Pharmacologic Treatment for Sleep …

Study Objectives: Serotonin, acting in the peripheral nervous system, can exacerbate sleep-related
apnea, and systemically administered serotonin antagonists reduce sleep-…

Study Objective: Animal data suggest that Δ 9 -TetraHydroCannabinol (Δ 9 THC) stabilizes
autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks …

Study Objective: Incremental withdrawal of serotonin during wake to sleep transition is
postulated as a key mechanism that renders the pharyngeal airway collapsible. While serotonin …

… Caffeine at all doses and time periods produced statistically significant decreases m SWS2
ranging from 29 to 88% as compared to control (P ~ 0.051. The intergroup drug effects on …

Serotonin enhancing drugs, including l-tryptophan and, more recently, fluoxetine and
paroxetine, have been tested as pharmacologic treatments for sleep apnea syndrome. Although …

The effects of adenosine (12.5 nmol/rat, icv) and 2′-deoxycoformycin (2.0 μmol/kg, ip) on
sleep and wakefulness were examined in rats. Adenosine significantly decreased …