Microtubulin binding sites as target for developing anticancer agents

M Islam, MN Iskander - Mini reviews in medicinal chemistry, 2004 - ingentaconnect.com
Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and
biophysical properties have made α-and β-tubulin, the main components of MTs, the subject …

Macrophage migration inhibitory factor: a therapeutic target across inflammatory diseases

AY Hoi, MN Iskander, EF Morand - Inflammation & Allergy-Drug …, 2007 - ingentaconnect.com
Macrophage migration inhibitory factor (MIF), a cytokine originally reported in the 1960s as
the prototypic T lymphokine, has emerged in recent years as a key factor regulating …

Antiinflammatory screening of the medicinal plant Gynura procumbens

MN Iskander, Y Song, IM Coupar… - Plant Foods for Human …, 2002 - Springer
Gynura procumbens isused in Thai folk medicine to treat topicalinflammation, rheumatism,
and viral ailments. In thepresent work, attempts were made to verify the folkmedicinal claim …

[HTML][HTML] A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences

…, SM Cutts, GM Neumann, MN Iskander… - Journal of Biological …, 2004 - ASBMB
When mitoxantrone is activated by formaldehyde it can form adducts with DNA. These occur
preferentially at CpG and CpA sequences and are enhanced 2–3-fold at methylated CpG …

Isolation of estrone from Moghat roots and from pollen grains of Egyptian date palm

ES Amin, O Awad, M Abd El Samad, MN Iskander - Phytochemistry, 1969 - Elsevier
The estrogenic substance in the roots of moghat (Clossostemon bruguieri, Sterculiaceae)
from Iraq, and in the pollen grains of date palm (Phoenix dactylifera, Egyptian variety, Samani) …

Investigation of structure–activity relationships in a series of glibenclamide analogues

E Yuriev, DCM Kong, MN Iskander - European journal of medicinal …, 2004 - Elsevier
In this study, the synthesis of 15 new glibenclamide analogues is described. The conformational
trends of these analogues were investigated using Monte Carlo conformational analysis…

Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity

…, SLA Munro, DJ Craik, MN Iskander… - Journal of medicinal …, 1993 - ACS Publications
The synthesis of a series of mono- and disubstituted JV-phenylanthranilic acids is described.
Substituents on the phenyl ring include Cl, CN, OH, CF3, Br, I, CH3, OCH3, and OCF2CF2H…

Stereochenols A and B, two quinones from Stereospermum chelonoides

MR Haque, KM Rahman, MN Iskander, CM Hasan… - Phytochemistry, 2006 - Elsevier
Two quinones, stereochenols A (1) and B (2) were isolated from a methanol extract of the
stem bark of Stereospermum chelonoides, in addition to the known naphthoquinones, …

Pregnancy following tension-free vaginal taping

MN Iskander, D Kapoor - International Urogynecology Journal, 2000 - Springer
Genuine stress incontinence is usually managed conservatively in women desirous of further
childbearing. Tension-free vaginal taping is a relatively new method of surgical treatment …

Synthesis, NMR studies and conformational analysis of oxazolidine derivatives of the β-adrenoreceptor antagonists metoprolol, atenolol and timolol

GP Moloney, DJ Craik, MN Iskander… - Journal of the Chemical …, 1998 - pubs.rsc.org
Formaldehyde-derived oxazolidine derivatives 4–7 of the β-adrenoreceptor antagonists
metoprolol 1, atenolol 2 and timolol 3 have been synthesised. Conformational analysis of 1–3 …