Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug‐metabolizing
enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive …

Adverse metabolic effects, such as diabetes mellitus, lipid abnormalities and weight gain,
have increasingly been recognised with the use of the newer, so-called atypical antipsychotic …

CYP1A2 is involved in the metabolism of several widely used drugs and endogenous
compounds, and in the activation of procarcinogens. Both genetic and environmental factors …

Background and Objective Many drugs, including proton pump inhibitors and certain
antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme. A …

Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately
7% of the Caucasian population. These individuals (poor metabolizers) carry deficient …

Objective: This review aimed to provide distinct dose recommendations for antidepressants
based on the genotypes of cytochrome P450 enzymes CYP2D6 and CYP2C19. This …

… S‐warfarin CL free values were 307.5 mL/min, 480.3 mL/min, and 881.3 mL/min. The mean
S‐… as those carrying mutated alleles (58–777 mL/min). No relationship was found between S‐…

ABSTRACT ABBREVIATIONS: CYP, cytochrome P450; PCR, polymerase chain reaction;
RFLP, restriction fragment length polymorphism; MA, metabolic ratio; kb, kilobase; wt, wild …

… The pH was adjusted to 3.5 by SM hydrochloric acid and 10 ml aliquots were frozen at -20C …
6 Dahl ML, Bertilsson L. Genetically variable metabolism of antidepressants and neuroleptic …

… This subject was already described by Dahl et al.ls to have the Xba I RFLP fragment of 54 kb.
… Bertilsson L, Dahl ML. Polymorphic drug oxidation: relevance to the treatment of psychiatric …