N-Oxides are oxidation products of tertiary amines. They were detected as a new class of
chemical compounds before 1900 and were later found to occur as constituents of living matter…

Biochemistry has a history of breathtaking successes and in addition has contributed
immensely to the progress of medicine during the past hundred years. Yet the history of …

Most drugs and other foreign compounds after being absorbed into an organism are known
to show an uneven distribution, often to an extreme degree. This fact reflects the …

… & MH Bickel: Prediction of drug distribution in distribution dialysis and in vivo from binding to
… Jachertz & MH Bickel: Adipose tissue distribution and chemical structure of basic lipophilic …

The binding of model drugs to human blood and individual blood components has been
determined by equilibrium dialysis and expressed in terms of classes of binding sites, …

Desmethylimipramine (DMI), a major metabolite of imipramine, elicits no obvious pharmacological
effects of its own but, in doses comparable to those used to treat primary depression …

Relationships between the binding and the distribution of drugs have been studied in vitro
and compared with in vivo data. By use of a standardized technique of distribution dialysis, 10 …

… MH Bickel … MH Bickel … whether added exogeneously to microsomal suspensions or
formed metabolically from imipramine (Bickel & Gigon, 1971). The compound even binds to cyto…

Adipose tissue kinetics of chlorpromazine and imipramine, two drugs which are more
lipophilic than thiopental, were studied in the rat. After single iv doses, the time-course of drug …

The association constants of the binding of chlorpromazine and imipramine to serum albumin
at low saturation of the protein were determined by a new experimental approach with the …