Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicity

KA Haberny, MG Paule, AC Scallet… - Toxicological …, 2002 - academic.oup.com
… The Mg ++ -binding site within the cation channel blocks ion permeability in a voltage- and
… blocked for at least 4–6 h at a threshold dose of 0.25 mg/kg (+) MK-801. This phenomenon is …

Zebrafish model in drug safety assessment

…, E Cuevas, SF Ali, MG Paule - Current Pharmaceutical …, 2014 - ingentaconnect.com
… [188] Kanungo J, Lantz S, Paule MG. In vivo imaging and quantitative analysis of changes
in axon length using transgenic zebrafish embryos. Neurotoxicol Teratol 2011; 33: 618-23. …

Attention deficit/hyperactivity disorder: characteristics, interventions and models

MG Paule, AS Rowland, SA Ferguson… - Neurotoxicology and …, 2000 - Elsevier
… For example, treatment with the antimitotic methylazoxymethanol acetate (4 mg/kg on …
Treatment with the synthetic glucocorticoid dexamethasone (DEX) (1.5 mg/kg on postnatal …

Ketamine-induced neuronal cell death in the perinatal rhesus monkey

…, TA Patterson, JP Hanig, MG Paule… - Toxicological …, 2007 - academic.oup.com
… In the present study, ketamine was given as an initial intramuscular injection (20 mg/kg)
followed by a continuous intravenous infusion at a rate of 20–50 mg/kg/h. Peak plasma …

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys

MG Paule, M Li, RR Allen, F Liu, X Zou… - Neurotoxicology and …, 2011 - Elsevier
Previously our laboratory has shown that ketamine exposure (24h of clinically relevant
anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys. …

Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: the Mayo Anesthesia Safety in Kids …

…, RT Wilder, J Sprung, D Hu, RG Voigt, MG Paule… - …, 2018 - pubs.asahq.org
Background Few studies of how exposure of children to anesthesia may affect neurodevelopment
employ comprehensive neuropsychological assessments. This study tested the …

Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells

…, JJ Schlager, SJ Oldenburg, MG Paule… - Toxicological …, 2010 - academic.oup.com
The current report examines the interactions of silver nanoparticles (Ag-NPs) with the
cerebral microvasculature to identify the involvement of proinflammatory mediators that can …

Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain

…, N Sadovova, X Zhang, JP Hanig, MG Paule… - International Journal of …, 2009 - Elsevier
… (20 mg/kg) to induce anesthesia followed by a continuous intravenous infusion at a rate of
20–50 mg/(kg … In this study, a ketamine dose of 20 mg/kg (intramuscularly) was used to induce …

Potential neurotoxicity of ketamine in the developing rat brain

…, X Zhang, X Fu, JP Hanig, MG Paule… - Toxicological …, 2009 - academic.oup.com
… of 5 or 10 mg/kg ketamine. However, in rats administered six injections of 20 mg/kg ketamine,
a … 1 or 3 times with 20 mg/kg ketamine or animals exposed to 5 or 10 mg/kg ketamine in a …

Fetal disposition of Δ9-tetrahydrocannabinol (THC) during late pregnancy in the rhesus monkey

JR Bailey, HC Cunny, MG Paule, W Slikker Jr - Toxicology and applied …, 1987 - Elsevier
Three late-term (Gestational Days 146–151) rhesus monkeys were given 0.3 mg/kg Δ 9 -tetrahydrocannabinol
(THC) intravenously via the maternal radial vein to quantify the placental …