Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons

…, J Carr, YJ Lee, CC Hsu, MD Faiman… - Journal of …, 2001 - Wiley Online Library
Glutamate-induced excitotoxicity has been implicated as an important mechanism underlying
a variety of brain injuries and neurodegenerative diseases. Previously we have shown that …

Elimination kinetics of disulfiram in alcoholics after single and repeated doses

MD Faiman, JC Jensen… - Clinical Pharmacology & …, 1984 - Wiley Online Library
… Jensen JC, Faiman MD: Determination of disulfiram and metabolites from biological fluids
by high-performance liquid chromatography. J Chromatogr 181:407-416, 1980. Jensen JC, …

In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N, N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram.

BW Hart, MD Faiman - Biochemical pharmacology, 1992 - europepmc.org
In summary, these data provide the first evidence that DETC-MeSO is a natural metabolite of
disulfiram, and a potent inhibitor of rat liver mitochondrial low Km ALDH both in vitro and in …

S-Methyl-N,N-Diethylthiocarbamate Sulfoxide Elicits Neuroprotective Effect against N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity

…, W Chen, JV Schloss, MD Faiman… - Journal of biomedical …, 2001 - karger.com
… DETC-MeSO was synthesized and the structure of DETC-MeSO verified by 1H NMR and
FAB-MS/MS as described by Hart and Faiman [8]. All other chemicals including NMDA, KA and …

Disulfiram metabolism as a requirement for the inhibition of rat liver mitochondrial low Km aldehyde dehydrogenase

JJ Yourick, MD Faiman - Biochemical pharmacology, 1991 - Elsevier
… d MD FAIMAN … Yourick JJ and Faiman MD, Comparative aspects of disuf~ram and its
metabolites in the … Hart BW, Yourick JJ and Faiman MD, S-Methyf-N,Ndiethyfthiolcarbamate: …

The role of lipid, free radical initiator, and oxygen on the kinetics of lipid peroxidation

RC Dirks, MD Faiman, ES Huyser - Toxicology and applied pharmacology, 1982 - Elsevier
The relationship between the concentration of unsaturated lipid, free radical initiator, and
oxygen concentration on the kinetics of lipid peroxidation was determined. The rate of lipid …

[PDF][PDF] Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N, N-diethylthiolcarbamate (DETC-ME). The terminal step in the …

A Madan, A Parkinson, MD Faiman - Drug metabolism and …, 1995 - researchgate.net
The present study investigated the role of rat and human cytochrome P450 enzymes in the
sulfoxidation of S-methyl N, N-dieth-ylthiolcarbamate(DETC-Me) to S-methyl N, N-…

Mode of action of taurine and regulation dynamics of its synthesis in the CNS

…, H Jin, T Foos, JV Schloss, K Davis, MD Faiman… - Taurine 4: Taurine and …, 2002 - Springer
Conclusion The regulation of taurine biosynthesis can be summarized as following: (i) When
neurons are stimulated, the arrival of action potential will open the voltage-dependent Ca 2…

Determination of GABA, glutamate and carbamathione in brain microdialysis samples by capillary electrophoresis with fluorescence detection

S Kaul, MD Faiman, CE Lunte - Electrophoresis, 2011 - Wiley Online Library
Disulfiram has been used as a deterrent in the treatment of alcohol abuse for almost 60
years. Our laboratory has shown that a disulfiram metabolite, S‐(N,N‐diethylcarbamoyl) …

Regulation of taurine biosynthesis and its physiological significance in the brain

JY Wu, XW Tang, JV Schloss, MD Faiman - Taurine 3: Cellular and …, 1998 - Springer
Cysteine sulfinic acid decarboxylase (CSAD), the rate-limiting enzyme in taurine biosynthesis,
was found to be activated under conditions that favor protein phosphorylation and …