Formation of 19 (S)-, 19 (R)-, and 18 (R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1
RM Laethem, M Balazy, JR Falck, CL Laethem… - Journal of Biological …, 1993 - ASBMB
When reconstituted with cytochrome b5 and NADPH cytochrome P450 oxidoreductase,
cytochrome P450 2E1 metabolized lauric, stearic, oleic, linoleic, linolenic, and arachidonic acid …
cytochrome P450 2E1 metabolized lauric, stearic, oleic, linoleic, linolenic, and arachidonic acid …
[HTML][HTML] S-Nitroglutathione, a product of the reaction between peroxynitrite and glutathione that generates nitric oxide
M Balazy, PM Kaminski, K Mao, J Tan… - Journal of Biological …, 1998 - ASBMB
… derived from 0.4 mm ONOO − or 0.1 mmGSNO 2 , … mmpotassium phosphate or 25 mm
bicarbonate buffer (pH 7.4) in the presence or absence of combinations of 1 mm GSH and 5.6 mm …
bicarbonate buffer (pH 7.4) in the presence or absence of combinations of 1 mm GSH and 5.6 mm …
Eicosanomics: targeted lipidomics of eicosanoids in biological systems
M Balazy - Prostaglandins & other lipid mediators, 2004 - Elsevier
Recent advancements in mass spectrometry, especially the development of electrospray
tandem mass spectrometry (ESI/LC/MS 2 ) and matrix-assisted laser desorption time-of-flight …
tandem mass spectrometry (ESI/LC/MS 2 ) and matrix-assisted laser desorption time-of-flight …
[HTML][HTML] Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors
…, H Jiang, C Yu, WH Wang, M Balazy… - The Journal of …, 2001 - Am Soc Clin Investig
… The amount of CO in samples was calculated from standard curves constructed with
abundance of ions m/z 28 and m/z 29 or m/z 31. Both standard curves were linear over the range …
abundance of ions m/z 28 and m/z 29 or m/z 31. Both standard curves were linear over the range …
Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides
MA Carroll, M Balazy, P Margiotta… - American Journal …, 1996 - journals.physiology.org
… ratio (m/z) 391 and m/z 301 but did not comigrate with lipoxygenase (5-, 8-, ll-, 12-, and 15-HETEs) …
of&450 HETEs and ouabain was 2 X lop6 M and 3 X lop3 M, respectively. …
of&450 HETEs and ouabain was 2 X lop6 M and 3 X lop3 M, respectively. …
Drugs that target lipoxygenases and leukotrienes as emerging therapies for asthma and cancer
CD Poff, M Balazy - Current Drug Targets-Inflammation & …, 2004 - ingentaconnect.com
Considerable amount of work has been done in the area of enzymatic and nonenzymatic
oxidation of arachidonic acid. This effort resulted in understanding of the functions of lipid …
oxidation of arachidonic acid. This effort resulted in understanding of the functions of lipid …
Cytochrome P450-derived renal HETEs: storage and release
MA Carroll, M Balazy, DD Huang, S Rybalova… - Kidney international, 1997 - Elsevier
… We took precautions to prevent spontaneous oxidation of AA during isolation and handling
of renal lipids by including 0.1 m of the antioxidant triphenylphosphine in all buffers. The lipid …
of renal lipids by including 0.1 m of the antioxidant triphenylphosphine in all buffers. The lipid …
Biological nitration of arachidonic acid
M Balazy, CD Poff - Current Vascular Pharmacology, 2004 - ingentaconnect.com
… C, Jiang H, Balazy M. Diffusion of peroxynitrite into the human platelet inhibits cyclooxygenase
via nitration of tyrosine residues. J Pharmacol Exp Ther 2000; 293: 222-9. [61] Balazy M. …
via nitration of tyrosine residues. J Pharmacol Exp Ther 2000; 293: 222-9. [61] Balazy M. …
Phospholipase A2 is involved in mediating the effect of extracellular Ca2+ on apical K+ channels in rat TAL
W Wang, M Lu, M Balazy… - American Journal of …, 1997 - journals.physiology.org
Raising extracellular Ca2+ (Ca2+o) stimulating the Ca(2+)-sensing receptor (CaR)
decreased the activity of the apical 70-pS K+ channel via a cytochrome P-450-dependent …
decreased the activity of the apical 70-pS K+ channel via a cytochrome P-450-dependent …
Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration
…, C Boisvert, P Hardy, K Jain, JR Falck, M Balazy… - Nature medicine, 2005 - nature.com
… We intravitreally injected rat pups with L-NAME (Sigma; 10 −5 M final intraocular concentration
based on estimated eye volume 29 ) before exposure to oxygen. We intravitreally injected …
based on estimated eye volume 29 ) before exposure to oxygen. We intravitreally injected …