Using physiological, pharmacological, and gene disruption approaches, we demonstrate
that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic …

Biological therapies such as tumor necrosis factor-α inhibitors have advanced the treatment
of rheumatoid arthritis, but one-third of patients do not respond to such therapy. Furthermore, …

Objective Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage
degradation in experimental osteoarthritis (OA). The wider impact of this pathway upon OA-…

Objective Serine proteinases activate the G protein–coupled receptor, proteinase‐activated
receptor 2 (PAR‐2), via cleavage and exposure of a tethered ligand. PAR‐2 is known to …

Protease-activated receptor-2 (PAR2) is one member of a small family of transmembrane, G-protein-coupled
receptors. These receptors are activated via cleavage of their N terminus by …

Objective Proteinase-activated receptor-2 (PAR 2 ) has been implicated in inflammatory
articular pathology. Using the collagen-induced arthritis model (CIA) the authors have explored …

Protease-activated receptor-2 (PAR-2) is known to be pro-inflammatory and increasing
evidence points to an inflammatory component in osteoarthritis. This investigation examined the …

Objective Joint injury involving destabilisation of the joint and damage to the articular
cartilage (eg, sports-related injury) can result in accelerated post-traumatic osteoarthritis (PTOA). …

Objective IĸB protein B‐cell lymphoma 3‐encoded protein (BCL3) is a regulator of the NF‐κB
family of transcription factors. NF‐κB signalling fundamentally influences the fate of bone‐…

AIMS: Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired
endothelial cell (EC) function and elevated angiotensin II levels may be central to the link …