[HTML][HTML] Angiotensin-converting enzyme 2 protects from severe acute lung failure
…, MA Crackower, A Fukamizu, CC Hui, L Hein… - Nature, 2005 - nature.com
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a
devastating clinical syndrome with a high mortality rate (30–60%) (refs 1 ). Predisposing …
devastating clinical syndrome with a high mortality rate (30–60%) (refs 1 ). Predisposing …
[HTML][HTML] Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease
…, BK Fleischmann, D Schübeler, L Hein - Nature …, 2014 - nature.com
The heart is a highly specialized organ with essential function for the organism throughout
life. The significance of DNA methylation in shaping the phenotype of the heart remains only …
life. The significance of DNA methylation in shaping the phenotype of the heart remains only …
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
L Hein, JD Altman, BK Kobilka - Nature, 1999 - nature.com
The sympathetic nervous system regulates cardiovascular function by activating adrenergic
receptors in the heart, blood vessels and kidney 1 . α 2 -Adrenergic receptors are known to …
receptors in the heart, blood vessels and kidney 1 . α 2 -Adrenergic receptors are known to …
Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction
D Fraccarollo, S Berger, P Galuppo, S Kneitz, L Hein… - Circulation, 2011 - Am Heart Assoc
Background— Mineralocorticoid receptor (MR) blockade improves morbidity and mortality
among patients with heart failure; however, the underlying mechanisms are still under …
among patients with heart failure; however, the underlying mechanisms are still under …
Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice
S Engelhardt, L Hein, F Wiesmann… - Proceedings of the …, 1999 - National Acad Sciences
Stimulation of cardiac β 1 -adrenergic receptors is the main mechanism that increases heart
rate and contractility. Consequently, several pharmacological and gene transfer strategies …
rate and contractility. Consequently, several pharmacological and gene transfer strategies …
[HTML][HTML] Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
…, AF Lopez, MP Brown, J Duyster, L Hein… - Nature …, 2021 - nature.com
Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR)
T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell …
T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell …
[HTML][HTML] Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation*♦
VO Nikolaev, M Bunemann, L Hein… - Journal of Biological …, 2004 - ASBMB
cAMP is a universal second messenger of many G-protein-coupled receptors and regulates
a wide variety of cellular events. cAMP exerts its effects via cAMP-dependent protein kinase (…
a wide variety of cellular events. cAMP exerts its effects via cAMP-dependent protein kinase (…
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
L Hein, GS Barsh, RE Pratt, VJ Dzau, BK Kobilka - Nature, 1995 - nature.com
ANGIOTENSIN II, a potent regulator of blood pressure and of water and electrolyte balance,
binds to two different G-protein-coupled receptors. The type-1 receptor (AT 1 ,) mediates the …
binds to two different G-protein-coupled receptors. The type-1 receptor (AT 1 ,) mediates the …
Cardiovascular Regulation in Mice Lacking α2-Adrenergic Receptor Subtypes b and c
RE Link, K Desai, L Hein, ME Stevens, A Chruscinski… - Science, 1996 - science.org
α 2 -Adrenergic receptors (α 2 ARs) are essential components of the neural circuitry regulating
cardiovascular function. The role of specific α 2 AR subtypes (α 2a , α 2b , and α 2c ) was …
cardiovascular function. The role of specific α 2 AR subtypes (α 2a , α 2b , and α 2c ) was …
Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough
M Philipp, M Brede, L Hein - American Journal of …, 2002 - journals.physiology.org
α 2 -Adrenergic receptors mediate part of the diverse biological effects of the endogenous
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α 2 -adrenergic …
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α 2 -adrenergic …