Ischaemic heart disease ( IHD ) remains a major cause of morbidity/mortality globally, firmly
established in W esternized or ‘developed’ countries and rising in prevalence in developing …

Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in
morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the …

G‐protein‐coupled receptors (GPCRs) are key mediators in cardiovascular physiology, yet
frontline therapies for heart disease target only a small fraction of the cardiac GPCR repertoire…

Background Sepsis is a multi-system syndrome that remains the leading cause of mortality
and critical illness worldwide, with hemodynamic support being one of the cornerstones of the …

Cholesterol-rich caveolar microdomains and associated caveolins influence sarcolemmal ion
channel and receptor function and protective stress signaling. However, the importance of …

Whilst the presence of 2 subphenotypes among the heterogenous Acute Respiratory
Distress Syndrome (ARDS) population is becoming clinically accepted, subphenotype-specific …

Background Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5
days of opioid receptor (OR) agonism induces persistent protection against ischemia-…

There is growing evidence that inflammation underpins many common diseases.
Inflammatory/immunomodulatory/immune mediators, such as cytokines, are key modulators of …

Despite advances in mechanical circulatory devices and pharmacologic therapies, heart
transplantation (HTx) is the definitive and most effective therapy for an important proportion of …

The acute respiratory distress syndrome (ARDS) describes a heterogenous population of
patients with acute severe respiratory failure. However, contemporary advances have begun to …