Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

Y Daaka, LM Luttrell, RJ Lefkowitz - Nature, 1997 - nature.com
Many of the G-protein-coupled receptors for hormones that bind to the cell surface can
signal to the interior of the cell through several different classes of G protein 1 , 2 , 3 , 4 . For …

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

LM Luttrell, RJ Lefkowitz - Journal of cell science, 2002 - journals.biologists.com
β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled
receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein-…

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

LM Luttrell, FL Roudabush, EW Choy… - Proceedings of the …, 2001 - National Acad Sciences
Using both confocal immunofluorescence microscopy and biochemical approaches, we
have examined the role of β-arrestins in the activation and targeting of extracellular signal-…

Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

…, SS Karnik, L Hunyady, LM Luttrell… - Proceedings of the …, 2003 - National Acad Sciences
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II)
or of a wild-type receptor with an Ang II analog ([sarcosine 1 ,Ile 4 ,Ile 8 ]Ang II) fails to …

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

LM Luttrell, Y Daaka, RJ Lefkowitz - Current opinion in cell biology, 1999 - Elsevier
Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation
of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the …

[HTML][HTML] Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase

Y Daaka, LM Luttrell, S Ahn, GJ Della Rocca… - Journal of Biological …, 1998 - ASBMB
The classical paradigm for G protein-coupled receptor (GPCR) signal transduction involves
the agonist-dependent interaction of GPCRs with heterotrimeric G proteins at the plasma …

[HTML][HTML] Role of c-Src tyrosine kinase in G protein-coupled receptorand Gβγ subunit-mediated activation of mitogen-activated protein kinases

LM Luttrell, BE Hawes, T van Biesen, DK Luttrell… - Journal of Biological …, 1996 - ASBMB
Several G protein-coupled receptors that interact with pertussis toxin-sensitive heterotrimeric
G proteins mediate Ras-dependent activation of mitogen-activated protein (MAP) kinases. …

Targeting the Receptor-Gq Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy

SA Akhter, LM Luttrell, HA Rockman, G Iaccarino… - Science, 1998 - science.org
Hormones and neurotransmitters may mediate common responses through receptors that
couple to the same class of heterotrimeric guanine nucleotide–binding (G) protein. For …

[HTML][HTML] Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor: a scaffold for G protein-coupled receptor-mediated Ras …

LM Luttrell, GJ Della Rocca, T van Biesen… - Journal of Biological …, 1997 - ASBMB
In many cells, stimulation of mitogen-activated protein kinases by both receptor tyrosine
kinases and receptors that couple to pertussis toxin-sensitive heterotrimeric G proteins proceed …

[HTML][HTML] Distinct β-arrestin-and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation

…, CL Cowan, RF Spurney, LM Luttrell… - Journal of Biological …, 2006 - ASBMB
Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related
peptide (PTH/PTHrP) receptor (PTH1R). The purpose of the present study was to identify the …