[HTML][HTML] Mechanisms and regulation of IL-22-mediated intestinal epithelial homeostasis and repair
L Patnaude, M Mayo, R Mario, X Wu, H Knight… - Life Sciences, 2021 - Elsevier
Aims Ulcerative colitis and Crohn's disease, collectively known as inflammatory bowel
disease (IBD), are chronic inflammatory disorders of the intestine for which key elements in …
disease (IBD), are chronic inflammatory disorders of the intestine for which key elements in …
[HTML][HTML] The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia (S1P1) and Hypertension (S1P3) in Rat
…, KE Harrington, RM Dinallo, JC Horan, L Patnaude… - PLoS …, 2012 - journals.plos.org
Sphingosine-1-phospate (S1P) and S1P receptor agonists elicit mechanism-based effects
on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P X receptor agonist) …
on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P X receptor agonist) …
[HTML][HTML] A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis …
ND Lewis, LA Patnaude, J Pelletier, DJ Souza… - PLoS …, 2014 - journals.plos.org
GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an
important role in the regulation of bile acid synthesis, lipid metabolism, and energy …
important role in the regulation of bile acid synthesis, lipid metabolism, and energy …
Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3
…, P Adusumalli, SN Desai, LA Patnaude… - The Journal of …, 2013 - journals.aai.org
Sphingosine-1-phosphate (S1P) receptors are critical for lymphocyte egress from secondary
lymphoid organs, and S1P receptor modulators suppress lymphocyte circulation. However, …
lymphoid organs, and S1P receptor modulators suppress lymphocyte circulation. However, …
[HTML][HTML] Optimized culture conditions for improved growth and functional differentiation of mouse and human colon organoids
…, M Mayo, T Melim, H Knight, L Patnaude… - Frontiers in …, 2021 - frontiersin.org
Background & Aims Diligent side-by-side comparisons of how different methodologies affect
growth efficiency and quality of intestinal colonoids have not been performed leaving a gap …
growth efficiency and quality of intestinal colonoids have not been performed leaving a gap …
G protein–coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a KCa1. 1 (BKCa)–dependent mechanism
RM Fryer, KJ Ng, SGN Mazurek, L Patnaude… - … of Pharmacology and …, 2014 - ASPET
Bile acids (BAs) and BA receptors, including G protein–coupled bile acid receptor 1 (GPBAR1),
represent novel targets for the treatment of metabolic and inflammatory disorders. …
represent novel targets for the treatment of metabolic and inflammatory disorders. …
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
…, N Moss, C Pargellis, UR Patel, L Patnaude… - Bioorganic & medicinal …, 2007 - Elsevier
The discovery of a series of potent, carboline-based MK2 inhibitors is described. These
compounds inhibit MK2 with IC 50 s as low as 10nM, as measured in a DELFIA assay. An X-ray …
compounds inhibit MK2 with IC 50 s as low as 10nM, as measured in a DELFIA assay. An X-ray …
Assay optimization: a statistical design of experiments approach
…, SW Mason, RM Nelson, LA Patnaude… - Clinics in laboratory …, 2007 - Elsevier
With the transition from manual to robotic HTS in the last several years, assay optimization
has become a significant bottleneck. Recent advances in robotic liquid handling have made it …
has become a significant bottleneck. Recent advances in robotic liquid handling have made it …
The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease
…, J Chime, S Lukas, L Patnaude… - American Journal …, 2021 - journals.physiology.org
Mouse and human data implicate the NOD1 and NOD2 sensors of the intestinal microbiome
and the associated signal transduction via the receptor interacting protein kinase 2 (RIPK2) …
and the associated signal transduction via the receptor interacting protein kinase 2 (RIPK2) …
Assay optimization: a statistical design of experiments approach
…, SW Mason, RM Nelson, LA Patnaude… - JALA: Journal of the …, 2006 - journals.sagepub.com
With the transition from manual to robotic HTS in the last several years, assay optimization
has become a significant bottleneck. Recent advances in robotic liquid handling have made it …
has become a significant bottleneck. Recent advances in robotic liquid handling have made it …