Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies
…, M Gronda, CA Goard, LG Rajewski… - American journal of …, 2014 - Wiley Online Library
The antimycotic ciclopirox olamine is an intracellular iron chelator that has anticancer activity
in vitro and in vivo. We developed an oral formulation of ciclopirox olamine and conducted …
in vitro and in vivo. We developed an oral formulation of ciclopirox olamine and conducted …
Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin
Opioid peptides are key regulators in cellular and intercellular physiological responses, and
could be therapeutically useful for modulating several pathological conditions. Unfortunately…
could be therapeutically useful for modulating several pathological conditions. Unfortunately…
Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis
Y Ma, M Baltezor, L Rajewski, J Crow… - Journal of Molecular …, 2019 - Springer
Ewing sarcoma (ES) are aggressive pediatric bone and soft tissue tumors driven by EWS-ETS
fusion oncogenes, most commonly EWS-FLI1. Treatment of ES patients consists of up to 9 …
fusion oncogenes, most commonly EWS-FLI1. Treatment of ES patients consists of up to 9 …
Preclinical pharmacokinetics of fosciclopirox, a novel treatment of urothelial cancers, in rats and dogs
…, P Ramamoorthy, K Heppert, L Rajewski… - … of Pharmacology and …, 2019 - ASPET
Pharmacokinetic studies in rats and dogs were performed to characterize the in vivo
performance of a novel prodrug, fosciclopirox. Ciclopirox olamine (CPX-O) is a marketed topical …
performance of a novel prodrug, fosciclopirox. Ciclopirox olamine (CPX-O) is a marketed topical …
Evaluation of intravenous and subcutaneous administration of a novel, excipient‐free, nanoparticulate formulation of paclitaxel in dogs with spontaneously occurring …
Carriers used to solubilize taxane chemotherapy drugs cause severe hypersensitivity.
Nanoparticle formulations can provide improved dissolution and bioavailability of taxanes. Thus, a …
Nanoparticle formulations can provide improved dissolution and bioavailability of taxanes. Thus, a …
Preclinical development of ciclopirox prodrug for the treatment of non-muscle invasive and muscle invasive bladder cancer.
…, T Ham, P Ranjarajan, P Ramamoorthy, L Rajewski… - 2018 - ascopubs.org
e14576 Background: Ciclopirox (CPX) is an antifungal agent contained in a number of FDA-approved
topical drug products. CPX possesses anticancer activity in a number of in vitro …
topical drug products. CPX possesses anticancer activity in a number of in vitro …
[HTML][HTML] Clinical proof of concept trial of oral ciclopirox olamine in patients with relapsed/refractory hematologic malignancy
…, L Patton, Y Jitkova, M Gronda, R Hurren, L Rajewski… - Blood, 2012 - Elsevier
Abstract 1372 Ciclopirox olamine (CPX) is a topical antifungal agent used for the treatment
of mild to moderate nail infection. Recently, we and others demonstrated both in vitro and in …
of mild to moderate nail infection. Recently, we and others demonstrated both in vitro and in …
A non-canonical MiT/TFE-dependent NRF2 program is a druggable vulnerability in multiple cancer types
…, S Kitajima, D Barbie, A Roy, M Baltezor, L Rajewski… - Cancer Research, 2023 - AACR
The transcription factor NRF2 is a master regulator of cellular responses to oxidative stress,
contributing to the pathogenesis of autoimmunity, metabolic disorders, and …
contributing to the pathogenesis of autoimmunity, metabolic disorders, and …
Mechanistic study of hydrocortisone release from devices of hydrocortisone esters of hyaluronic acid.
LG Rajewski - 1994 - elibrary.ru
The mechanism of hydrocortisone release from devices of a model pendant chain system,
hydrocortisone esters of hyaluronic acid was investigated. The contributions of solvation of the …
hydrocortisone esters of hyaluronic acid was investigated. The contributions of solvation of the …
[HTML][HTML] Small molecule inhibitor of CBFβ-RUNX binding for RUNX transcription factor driven cancers
Transcription factors have traditionally been viewed with skepticism as viable drug targets,
but they offer the potential for completely novel mechanisms of action that could more …
but they offer the potential for completely novel mechanisms of action that could more …